HOME >> BIOLOGY >> NEWS
Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report

" Hausladen said.

The actions of NO in this experiment also resemble the process by which oxygen affects cell health and disease, the scientists say.

"Now we have demonstrated that an NO group, attached to a thiol within a cell, has regulatory function," Stamler said. "There has been growing evidence that NO does its work in the body by signaling genes, but no one has found proof before this."

Both oxygen and NO are vital to life processes, but too much of either can damage cells. To keep the amount of oxygen and NO in balance, cells have built-in systems to eliminate the excess. One way to do that is to have transcription factor sensors that get turned on when too much oxygen or NO is present.

In fact, bacterial cells attempt to control both excess oxygen and excess nitrogen with the same OxyR transcription factor.

In human cells, constant vigilance against excess oxygen and NO takes a toll over time. When the system is out of balance, perhaps when a transcription factor is mutated, disease can result, the scientists say.

"It is a parallel process to what is known as oxidative stress, in which an excess of oxygen in cells can lead to a host of diseases, as well as the cumulative damage we call aging," Stamler said. "NO has a similar deleterious function, which we call nitrosative stress. When a cell can't contain the flow of SNO, the nitrosative stress can well be theorized to contribute to cancer, arthritis, neurodegenerative diseases, stroke and hardening of the arteries -- all diseases associated with NO."


'"/>

Contact: Karyn Hede George
georg016@mc.duke.edu
919-660-1301
Duke University Medical Center
14-Aug-1996


Page: 1 2 3 4

Related biology news :

1. Nitric oxide may change basic understanding of cellular machinery
2. Nitric oxide has important role in fever regulation, new study says
3. Nitric oxide-like drug could revive a failing heart
4. The building blocks of erection: Nitric oxide...and more nitric oxide
5. Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
6. Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
7. First glimpse of DNA binding to viral enzyme
8. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
9. 2nd media alert First Scientific Conference on Childhood Leukaemia
10. First International Scientific Conference on Childhood Leukaemia
11. First ever standards linking climate change, biodiversity and poverty seek global peer review

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/23/2017)... -- The report "Gesture Recognition and Touchless Sensing Market by Technology ... Forecast to 2022", published by MarketsandMarkets, the market is expected to be worth ... and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... Ca (PRWEB) , ... August 14, 2017 , ... ... poorly characterized and performing antibodies. Key researchers in the antibody community have recently ... characterization and consistency for antibodies in the laboratory. , The team ...
(Date:8/11/2017)... 11, 2017  Market researcher Kalorama Information ... article regarding the telemedicine market.  The telemedicine ... Information.  The article, "Heart and Asthma ...  used information from Kalorama Information,s Remote Patient ... Market  (Sleep, Diabetes, Vital Signs /EKG ...
(Date:8/11/2017)... ... August 11, 2017 , ... ... and, in particular, more natural alternatives to synthetic ingredients,” said Matt Hundt, President ... Wave, with the established manufacturing presence and know-how of Biorigin will allow us ...
(Date:8/10/2017)... , ... August 09, 2017 , ... ... medicine applications in the clinic is here. The team at Capricor Therapeutics, Inc. ... conditioned medium for clinical studies. , Dr. Travis Antes, head of analytical ...
Breaking Biology Technology:
Cached News: