HOME >> BIOLOGY >> NEWS
Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report

" Hausladen said.

The actions of NO in this experiment also resemble the process by which oxygen affects cell health and disease, the scientists say.

"Now we have demonstrated that an NO group, attached to a thiol within a cell, has regulatory function," Stamler said. "There has been growing evidence that NO does its work in the body by signaling genes, but no one has found proof before this."

Both oxygen and NO are vital to life processes, but too much of either can damage cells. To keep the amount of oxygen and NO in balance, cells have built-in systems to eliminate the excess. One way to do that is to have transcription factor sensors that get turned on when too much oxygen or NO is present.

In fact, bacterial cells attempt to control both excess oxygen and excess nitrogen with the same OxyR transcription factor.

In human cells, constant vigilance against excess oxygen and NO takes a toll over time. When the system is out of balance, perhaps when a transcription factor is mutated, disease can result, the scientists say.

"It is a parallel process to what is known as oxidative stress, in which an excess of oxygen in cells can lead to a host of diseases, as well as the cumulative damage we call aging," Stamler said. "NO has a similar deleterious function, which we call nitrosative stress. When a cell can't contain the flow of SNO, the nitrosative stress can well be theorized to contribute to cancer, arthritis, neurodegenerative diseases, stroke and hardening of the arteries -- all diseases associated with NO."


'"/>

Contact: Karyn Hede George
georg016@mc.duke.edu
919-660-1301
Duke University Medical Center
14-Aug-1996


Page: 1 2 3 4

Related biology news :

1. Nitric oxide may change basic understanding of cellular machinery
2. Nitric oxide has important role in fever regulation, new study says
3. Nitric oxide-like drug could revive a failing heart
4. The building blocks of erection: Nitric oxide...and more nitric oxide
5. Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
6. Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
7. First glimpse of DNA binding to viral enzyme
8. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
9. 2nd media alert First Scientific Conference on Childhood Leukaemia
10. First International Scientific Conference on Childhood Leukaemia
11. First ever standards linking climate change, biodiversity and poverty seek global peer review

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... Feb. 2, 2016  BioMEMS devices deployed ... focused on medical screening and diagnostic applications, ... Wearable devices that facilitate and assure continuous ... movement are being bolstered through new opportunities ... signal acquisition coupled with wireless connectivity and ...
(Date:2/2/2016)... Checkpoint Inhibitors for Cancer – Explore ... you interested in the future of cancer drugs? ... Visiongain,s report gives those predictions to 2026 at ... Avoid falling behind in data or losing ... those emerging cancer therapies can achieve. There you ...
(Date:2/2/2016)...   Parabon NanoLabs (Parabon) announced today ... Office and the Defense Forensics and Biometrics Agency ... company,s Snapshot Kinship Inference software for ... defense-related DNA forensics.  Although Snapshot is best known ... ancestry from DNA evidence), it also has the ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... , Feb. 12, 2016  BD (Becton, Dickinson and ... technology company, today announced the launch of the BD ... and Technology (AGBT) Meeting. --> ... genomic research by providing cost effective NGS library preparation ... a high-throughput, fully integrated, next generation sequencing (NGS) library ...
(Date:2/11/2016)... (NASDAQ: NBIX ) today announced its financial results for the ... --> --> For the fourth quarter of 2015, ... loss per share, compared to a net loss of $19.4 million, ... For the year ended December 31, 2015, the Company reported a ... compared to a net loss of $60.5 million, or $0.81 loss ...
(Date:2/11/2016)...  Spectra BioPharma Selling Solutions (Spectra) is a ... companies the experience, expertise, operational delivery and customer ... teams. Created in concert with industry leading commercial ... and tactical needs of its clients by providing ... personal and non-personal promotion. --> ...
(Date:2/11/2016)... , February 11, 2016 ... Corporation ("PositiveID" or "Company") (OTCQB: PSID), a life ... today that its Thermomedics subsidiary, which markets the ... its growth plan in January 2016, including entering ... increasing sequential monthly sales growth, and establishing several ...
Breaking Biology Technology:
Cached News: