HOME >> BIOLOGY >> NEWS
Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report

" Hausladen said.

The actions of NO in this experiment also resemble the process by which oxygen affects cell health and disease, the scientists say.

"Now we have demonstrated that an NO group, attached to a thiol within a cell, has regulatory function," Stamler said. "There has been growing evidence that NO does its work in the body by signaling genes, but no one has found proof before this."

Both oxygen and NO are vital to life processes, but too much of either can damage cells. To keep the amount of oxygen and NO in balance, cells have built-in systems to eliminate the excess. One way to do that is to have transcription factor sensors that get turned on when too much oxygen or NO is present.

In fact, bacterial cells attempt to control both excess oxygen and excess nitrogen with the same OxyR transcription factor.

In human cells, constant vigilance against excess oxygen and NO takes a toll over time. When the system is out of balance, perhaps when a transcription factor is mutated, disease can result, the scientists say.

"It is a parallel process to what is known as oxidative stress, in which an excess of oxygen in cells can lead to a host of diseases, as well as the cumulative damage we call aging," Stamler said. "NO has a similar deleterious function, which we call nitrosative stress. When a cell can't contain the flow of SNO, the nitrosative stress can well be theorized to contribute to cancer, arthritis, neurodegenerative diseases, stroke and hardening of the arteries -- all diseases associated with NO."


'"/>

Contact: Karyn Hede George
georg016@mc.duke.edu
919-660-1301
Duke University Medical Center
14-Aug-1996


Page: 1 2 3 4

Related biology news :

1. Nitric oxide may change basic understanding of cellular machinery
2. Nitric oxide has important role in fever regulation, new study says
3. Nitric oxide-like drug could revive a failing heart
4. The building blocks of erection: Nitric oxide...and more nitric oxide
5. Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
6. Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
7. First glimpse of DNA binding to viral enzyme
8. First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
9. 2nd media alert First Scientific Conference on Childhood Leukaemia
10. First International Scientific Conference on Childhood Leukaemia
11. First ever standards linking climate change, biodiversity and poverty seek global peer review

Post Your Comments:
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
(Date:3/23/2015)... March 23, 2015  In the 2014 fiscal year, ... conviction losses. This figure accounts for a fraction of ... The Nilson Report, exceeds $11 billion globally. The polygraph ... a crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test ...
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ... - Global Strategic Business Report" report to their offering. ... Geometry in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Rest of World. Annual estimates and forecasts are ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
(Date:3/27/2015)... (PRWEB) March 27, 2015 Governor Andrew ... application period for 43North - the world’s largest business ... a grand prize of $1 million, six $500,000 awards ... around the world to compete for prizes that will ... in the Western New York region. , "Last ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 The Market ... formed a strategic alliance with Designing Gig LLC to ... clients. , “Forging this alliance with Designing ... Now we can extend a comprehensive, end-to-end, digital solution ... strategy, and execution,” said Chuck Miller, president of The ...
(Date:3/26/2015)... , March 26, 2015 PAREXEL ... global clinical research organization , announced ... definitive agreement to acquire all of the ... a leading provider of specialized pharmacovigilance services, ... the collection, detection, assessment, monitoring, and prevention ...
(Date:3/26/2015)... NJ (PRWEB) March 26, 2015 WriteResult, ... partnered with researchers from Yale University’s School of Public ... by study participants during a 4 month-long project. The ... of providing low income families with free access to ... habits and diet-related health concerns like high blood pressure, ...
Breaking Biology Technology:Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3
Cached News: