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Nitric oxide has important role in fever regulation, new study says

were exposed to.

For his studies, Dr. Kozak used lipopolysaccharide or endotoxin, a standard laboratory fever inducer derived from gram-negative bacteria that can cause inflammation throughout the body or septic shock. He also used turpentine oil, another commonly used lab agent which induces bacteria-free tissue necrosis that results in only localized inflammation.

As an example of the impact of the different infectious agents, the mice missing inducible nitric oxide synthase, which maintains fever, experienced a reduced fever in response to the systemic infection resulting from exposure to endotoxin. But the fact that they were missing the enzyme had no effect on their response to fever induced during localized inflammation.


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Contact: Toni Baker
tbaker@mail.mcg.edu
706-721-4421
Medical College of Georgia
30-May-2003


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