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Nitric oxide-like drug could revive a failing heart

ase all contribute to the condition. Although the failing heart keeps working, people with the condition become increasingly short of breath and tired, even with minimal exertion.

Kass and colleagues studied 11 dogs with heart failure and nine without, comparing the effects of nitroxyl anion, nitric oxide and nitroglycerin on the heart.

Nitroxyl anion worked well in both failing and normal hearts. Furthermore, it greatly enhanced the influence of dobutamine, another stimulator of heart function. When combined with nitroglycerin, dobutamine's effects are stifled, but added to nitroxyl anion the effectiveness is doubled. Nitroxyl anion also increased calcitonin gene-related peptide by 100 percent in healthy animals, and nearly 200 percent in heart failure dogs, supporting a proposed role of this compound to assist the failing heart. Neither nitric oxide nor nitroglycerin affected CGRP.


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Contact: Karen Blum
kblum@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
14-Apr-2003


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