HOME >> BIOLOGY >> NEWS
Nitric oxide may change basic understanding of cellular machinery

appeared with the addition of such tiny amounts of NO," Stamler said.

Two of the novel interactions discovered in yeast cells occurred in mouse cells only in the presence of NO, the researchers found. "The interactions seen in yeast turned out to be dramatically important in deciding the fate of mouse cells," he said.

Stamler's group suggests that NO regulates a broad spectrum of cellular reactions. NO might be as fundamentally important as phosphate in controlling cellular behavior, Stamler said. The addition of phosphate, known as phosphorylation, is the primary on-off switch for proteins that control basic life processes.

The Duke-based team's earlier work had revealed an unexpected role for nitric oxide. In blood cells, the NO molecule attaches to hemoglobin molecules, influencing oxygen delivery to tissues. However, said Stamler, the new studies suggest a broader role for NO in the body by revealing that the molecule influences interactions of a multitude of proteins.

The finding might have additional ramifications for understanding disease processes, said Stamler. Levels of NO commonly change in patients who have disease. For example, NO concentrations increase in patients with asthma. The finding that NO directly affects fundamental life reactions suggests that changes in cellular concentrations of the molecule might underlie some disease symptoms, Stamler said. Elucidating those effects could lead to new therapies.


'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
31-Jul-2003


Page: 1 2 3

Related biology news :

1. Nitric oxide has important role in fever regulation, new study says
2. Nitric oxide-like drug could revive a failing heart
3. The building blocks of erection: Nitric oxide...and more nitric oxide
4. Nitric Oxide Found To Control Cells By Turning On Genes; Suggests New Role In Health And Disease
5. Nitric Oxide May Hold Key To First Treatment For Deadly Form Of Malaria, Duke Scientists Report
6. Duke Researchers Discover Central Role Of Nitric Oxide In Hemoglobin Action
7. Long-term effects of carbon monoxide poisoning are an autoimmune reaction
8. Natural mineral locks up carbon dioxide
9. Impact of Earths rising atmospheric carbon dioxide found in world oceans
10. Underground carbon dioxide storage reduces emissions
11. Increased atmospheric carbon dioxide promotes algal growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
(Date:10/7/2017)... Arizona (PRWEB) , ... October ... ... 15 years’ experience providing advanced instruments and applications consulting for microscopy and ... in-house expertise in application consulting, Nanoscience Analytical offers a broad range of ...
Breaking Biology Technology:
Cached News: