Nomadic outposts of transplanted stem cells tracked in Stan...( STANFORD Calif.

Nomadic outposts of transplanted stem cells tracked in Stanford study

STANFORD, Calif. - Doctors regularly inject stem cells into patients whose bone marrow has been destroyed by chemotherapy or radiation, but they haven't known where these cells go after being injected. Research at the Stanford University School of Medicine has yielded an unexpected answer: when injected into mice, these cells may set up camp in one tissue early on but then move to another location or disappear entirely.

Published in the Dec. 15 online edition of the Proceedings of the National Academies of Science, the work upsets current thinking that transplanted stem cells find a habitable niche, settle in for the long haul and begin producing new blood cells. Instead, the newly transplanted cells drift throughout the body, nestling in one of a few homes where their populations subsequently wax and wane until some finally flourish.

Researchers said the procedure used to follow the injected cells' movements could one day help scientists hone their techniques for transplanting bone-marrow stem cells in humans and optimize therapies for cancer and immunodeficiencies. Developing these types of new stem cell-based treatments for cancer is among the primary goals of Stanford's Institute for Cancer/Stem Cell Biology and Medicine.

Yu-An Cao, PhD, a research associate and first author of the paper, said that until now injecting bone-marrow stem cells into a patient was like injecting them into a black box. "We didn't know where those cells were going," he said. Watching the fates of these cells after transplantation had raised more questions than it answered. He said in testing a new protocol, they now can watch to see whether the cells proliferate more quickly or if the patterns of inhabitation are altered.

"We are really curious about what is happening," Cao said. "We want to know why the process is so dynamic with unpredictable fates for the initial stem cell foci. There's no obvious reason for the stem cells to leave what appears
'"/>

Contact: Mitzi Baker
650-725-2106
Stanford University Medical Center
15-Dec-2003

Page: 1 2 3
Related biology news :

1. Study may improve survival of transplanted livers
2. Researchers grow breast cancer tissue from transplanted mammary stem cells
3. Brain stem cells are not rejected when transplanted
4. World first for Swedish researchers mice born from transplanted wombs
5. Study shows first direct evidence that transplanted muscle cells can take root in damaged hearts
6. Study yields new clues on bodys rejection of transplanted organs
7. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
8. Researchers develop fast track way to discover how cells are regulated
9. Chemical signals health of brain cells Symposium
10. New dye directly reveals activated proteins in living cells
11. NJIT professor receives Presidential Award for breakthrough research with adult stem cells

Post Your Comments:

(Date:11/24/2009)...oors to understanding how sounds associated with N...mal or if they hear it at all. , The same type ... uses to detect flaws in the space shuttle,s behem...to peek inside the giant head of a whale. The scan...s of a whale,s hearing anatomy using a breakthroug...

(Date:11/24/2009)...ge of Medical Toxicology (ACMT) have signed an agr...ournal of Medical Toxicology (JMT), the official ...was previously published by the University of Penn...ology , an international, peer-reviewed journal, i...of medical toxicology. The quarterly journal focu...

(Date:11/24/2009)...09) New research on bacterial communities through...ictable temporal patterns, suggesting that scienti...itoring climate change in the polar regions. The s...he National Academy of Sciences Early Edition, sh...hifted synchronously over time, correlating with s...

Breaking Biology News(10 mins):Rocket science leads to new whale discovery 2 Springer and the American College of Medical Toxicology to work together 2 Researchers establish common seasonal pattern among bacterial communities in Arctic rivers 2 Experts to Review Quality Improvement Programs to Prevent Preterm Birth 57668 1 Experts to Review Quality Improvement Programs to Prevent Preterm Birth 57668 2 Experts to Review Quality Improvement Programs to Prevent Preterm Birth 57668 3 Ulcer Preventative May Raise Pneumonia Risks 57664 1 Ulcer Preventative May Raise Pneumonia Risks 57664 2 John J Young Jr Joins SRI Board of Directors 14149 1 John J Young Jr Joins SRI Board of Directors 14149 2 John J Young Jr Joins SRI Board of Directors 14149 3

[1] Rocket science leads to new whale discovery [1] Springer and the American College of Medical Toxicology to work together [0] Researchers establish common seasonal pattern among bacterial communities in Arctic rivers

(Date:11/24/2009)...GARYandBLENHEIM,Ontario,Nov.24/PRNewswire-FirstCal...ngtheassetsofHylandSeeds,adivisionofThompsonsLimit...urtherexpandDowAgroSciences,currentseedsbusinessas...M) in 2010 andDowAgroSciencesHerbicideTolerantTr...xpectedinthenearfuture. ,, "Thisacquisitionbrin...

(Date:11/24/2009)... Health care employment grew by 29...ly one to show consistent growth during the U.S. r... remain in trouble, and health systems are coming ..., instead of just administrators. , ...e employment continued growing in October despite ...

(Date:11/24/2009)...MATEO,Calif.,Nov.24/PRNewswire-FirstCall/--Neuroge...cusedondevelopingandcommercializingnovelpainmanage...sidentandChiefExecutiveOfficer,isscheduledtopresen...obeheldDecember1-2,2009atTheNewYorkPalaceHotelinNe...,ChiefFinancialOfficer,willbeavailabletorespondtoq...

(Date:11/24/2009)... The FBI recently approved the Prome...participating in or generating DNA records for the... Madison, WI USA (PRWEB) -- The FBI recently a...for use by laboratories participating in, or gener...em (NDIS). NDIS currently contains more than seven...

Breaking Biology Technology:Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 2 Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds 3 The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2 The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3 The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4 NeurogesX to Present at Piper Jaffray Health Care Conference 2 NeurogesX to Present at Piper Jaffray Health Care Conference 3 NDIS Approval of Promega PowerPlex Kit Clears Path for More DNA Profiles to be Added to U.S. Database 2

[0] Dow AgroSciences Canada Announces Agreement to Acquire Hyland Seeds [0] The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close [0] NeurogesX to Present at Piper Jaffray Health Care Conference [0] NDIS Approval of Promega PowerPlex Kit Clears Path for More DNA Profiles to be Added to U.S. Database

Other News:

...popularity of coffee grows, a niche market for sha...on programs now exist to verify shade coffee is gr...re plants intact than farming for sun-favoring var...tsch's* paper, (University of Michigan, Ann Arbor)...

...sts have taken an important step toward creating a...the response of the immune system with unprecedent...erpes virus, scientists at the University of Roche...etic information that created a carefully crafted ...

...8, 2004) Bethesda, MD Concurrent with the nationa...ies about how the body controls appetite and food ...identified a close relationship between the gastro...ating food intake. The relationship is expressed i...

... international competition to design a new scienti...treme environments Antarctica - is launched this ...al Institute of British Architects (RIBA). Locate...ng ice shelf, the new complex will be self-suffici...

It's better in the shade 2 Herpes tool allows researchers to customize Alzheimer's vaccine 2 Herpes tool allows researchers to customize Alzheimer's vaccine 3 Infusion of two peptides acts to accelerate appetite satisfaction 2 Infusion of two peptides acts to accelerate appetite satisfaction 3 Design competition for new Antarctic Research Station 2

It's better in the shade Herpes tool allows researchers to customize Alzheimer's vaccine Infusion of two peptides acts to accelerate appetite satisfaction Design competition for new Antarctic Research Station

...word and enjoying a range of activities and intere...ning a healthy brain in older age, but the reasons...t the University of Edinburgh are seeking to ident...unused brain cells, but are re-awakened in active ...

...ith their roots and later releasing it from their ...he climate. In fact, in vegetated ecosystems, plan...to the atmosphere, with plant roots controlling th... assume that roots are shallow -- usually within 6...

...ic the bodies own bone formation and deposition pr... bioactive characteristics onto otherwise bioinert... a bone-like apatite layer. This means that, when ...cult to distinguish the implant as a foreign objec...

...ists at the University of Texas Medical Branch at ... connection between the hepatitis C virus and live...to the one that links the human papilloma virus (H...er, according to Dr. Stanley M. Lemon, the senior ...

'Survival' genes hold key to healthy brains in babies and the elderly 2 Climate models need deeper roots, scientists say 2 Texas scientists discover how a hepatitis C protein promotes liver cancer 2

'Survival' genes hold key to healthy brains in babies and the elderly Climate models need deeper roots, scientists say New biomimetic process used to grow artificial bone for better implants and prosthetics Texas scientists discover how a hepatitis C protein promotes liver cancer

Nomadic outposts of transplanted stem cells tracked in Stan...( STANFORD Calif. - Doctors regularly in...)