HOME >> BIOLOGY >> NEWS
Non-toxic peptide blocks spread of prostate cancer in rats

ANN ARBOR---University of Michigan scientists have developed a new cancer-inhibiting peptide, or chain of amino acids, that has proven to be effective at preventing metastatic prostate cancer from spreading to other organs in laboratory rats. Rats treated systemically with the new peptide developed smaller primary tumors and fewer lung metastases than untreated rats and showed no toxic side effects from the treatment. The peptide was effective even if primary tumors were allowed to grow to a large size before surgery and peptide treatment began. If future studies show the peptide works as well in people, it could be the basis for a new approach to cancer therapy. In an article published in the Jan. 15 issue of Cancer Research, U-M scientists present results from an extensive series of experiments which document the peptide's ability to block cancer cells' invasive activity and limit the growth and spread of tumors in laboratory rats. U-M scientist Donna L. Livant, Ph.D., created the peptide by changing just one amino acid in a short sequence of a common blood protein called fibronectin, which circulates freely through the body in blood plasma, lymph, serum and interstitial fluid around cells. When tissue is damaged, fibronectin at the injury site fragments and diffuses outward. Unlike intact fibronectin, which is present everywhere in the body, these fragments bind to fibronectin receptors on cells surrounding damaged tissue, which stimulates them to invade and repair the injury. The downside to this process, according to Livant---an assistant professor of cellular biology in the U-M Medical School---is that cancer cells can mutate so that intact fibronectin stimulates them to invade surrounding tissue also. "Cancer is the price we pay for our ability to heal from wounds," Livant said. "When intact fibronectin stimulates cancer cells to invade, they can easily reach the blood or lymphatic system and metastasize or spread to other parts
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
(734)647-1844
University of Michigan
24-Jan-2000


Page: 1 2 3 4

Related biology news :

1. Study: Mothers turn fearless when peptide level drops
2. Infusion of two peptides acts to accelerate appetite satisfaction
3. Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles
4. Protease-inhibitor cocktail protects, increases anti-microbial action of promising new peptide
5. Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
6. Zengen, Inc. receives patent application approval for proprietary peptide technology
7. Scientists develop super peptide that kills Candida albicans
8. Patients with serious kidney disorder produce natriuretic peptides at above average rates
9. UB dental researchers find novel peptide in saliva that kills broad range of fungi and bacteria
10. Antimicrobial peptides: new weapons to fight infection
11. Regulation of vascular tone by a secreted mitochondrial peptide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... Research and Markets has announced the addition of the ... The report forecasts the biometrics ... a CAGR of 12.28% during the period 2016-2020. ... with inputs from industry experts. The report covers the market landscape ... includes a discussion of the key vendors operating in this market. ...
(Date:6/22/2016)... June 22, 2016  The American College of Medical Genetics ... Executive Magazine as one of the fastest-growing trade shows ... at the Bellagio in Las Vegas . ... percentage of growth in each of the following categories: net ... and number of attendees. The 2015 ACMG Annual Meeting was ...
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Alex,s Lemonade Stand Foundation ... that it will open a state-of-the-art bioinformatics lab, using ... research. This announcement comes as Liz Scott , ... National Cancer Moonshot Summit in Washington, D.C. ... as a participant and advocate of pediatric cancer research ...
(Date:6/27/2016)... , June 27, 2016  Global demand for ... percent through 2020 to $7.2 billion.  This market ... beverages, cleaning products, biofuel production, animal feed, and ... diagnostics, and biocatalysts). Food and beverages will remain ... by increasing consumption of products containing enzymes in ...
(Date:6/27/2016)... - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the Company") announces ... Clean Technology Fund I, LP and Clean Technology Fund ... venture capital funds which together hold approximately 59% of ... as converted basis), that they have entered into an ... in Biorem to TUS Holdings Co. Ltd. ("TUS") (en.tusholdings.com) ...
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
Breaking Biology Technology:
Cached News: