HOME >> BIOLOGY >> NEWS
Non-toxic peptide blocks spread of prostate cancer in rats

ANN ARBOR---University of Michigan scientists have developed a new cancer-inhibiting peptide, or chain of amino acids, that has proven to be effective at preventing metastatic prostate cancer from spreading to other organs in laboratory rats. Rats treated systemically with the new peptide developed smaller primary tumors and fewer lung metastases than untreated rats and showed no toxic side effects from the treatment. The peptide was effective even if primary tumors were allowed to grow to a large size before surgery and peptide treatment began. If future studies show the peptide works as well in people, it could be the basis for a new approach to cancer therapy. In an article published in the Jan. 15 issue of Cancer Research, U-M scientists present results from an extensive series of experiments which document the peptide's ability to block cancer cells' invasive activity and limit the growth and spread of tumors in laboratory rats. U-M scientist Donna L. Livant, Ph.D., created the peptide by changing just one amino acid in a short sequence of a common blood protein called fibronectin, which circulates freely through the body in blood plasma, lymph, serum and interstitial fluid around cells. When tissue is damaged, fibronectin at the injury site fragments and diffuses outward. Unlike intact fibronectin, which is present everywhere in the body, these fragments bind to fibronectin receptors on cells surrounding damaged tissue, which stimulates them to invade and repair the injury. The downside to this process, according to Livant---an assistant professor of cellular biology in the U-M Medical School---is that cancer cells can mutate so that intact fibronectin stimulates them to invade surrounding tissue also. "Cancer is the price we pay for our ability to heal from wounds," Livant said. "When intact fibronectin stimulates cancer cells to invade, they can easily reach the blood or lymphatic system and metastasize or spread to other parts
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
(734)647-1844
University of Michigan
24-Jan-2000


Page: 1 2 3 4

Related biology news :

1. Study: Mothers turn fearless when peptide level drops
2. Infusion of two peptides acts to accelerate appetite satisfaction
3. Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles
4. Protease-inhibitor cocktail protects, increases anti-microbial action of promising new peptide
5. Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
6. Zengen, Inc. receives patent application approval for proprietary peptide technology
7. Scientists develop super peptide that kills Candida albicans
8. Patients with serious kidney disorder produce natriuretic peptides at above average rates
9. UB dental researchers find novel peptide in saliva that kills broad range of fungi and bacteria
10. Antimicrobial peptides: new weapons to fight infection
11. Regulation of vascular tone by a secreted mitochondrial peptide

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Non toxic peptide blocks spread prostate cancer rats

(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/143028 for MINIATURE, ... ENERGY TRANSFER  NXT-ID introduces a new ... This patent surrounds the use of miniature antenna ...
(Date:4/1/2015)... Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces the ... wallets is underway to early access pre-order customers. ... usage at retail outlets including Walmart, Target, AT&T, Dunkin, ... Wocket was accepted at all outlets and very easy ...
(Date:3/26/2015)... , March 26, 2015 ... family, social, recreation and athletic club, today announced it ... to allow freedom of movement for members and staff, ... "Following a comprehensive process, we selected FST,s IMID Access ... and convenience for our members and staff, in addition ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
(Date:4/17/2015)...  US-Australian drug discovery company, Novogen, today announced ... with the Feinstein Institute for Medical Research (,Feinstein ... to collaborate with the objective of developing effective ... brings together the drug discovery expertise of Novogen ... Feinstein Institute in neurosciences and oncology. ...
(Date:4/17/2015)... 2015 BellBrook Labs announced today ... for the powerful Orthogonal Pooled Screening (OPS) Platform ... at the Lankenau Institute for Medical Research (LCGC) ... measurably improve successful drug discovery outcomes using far ... drug-like libraries available nowhere else, coupled to a ...
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
(Date:4/16/2015)... 2015 Proove Biosciences , Inc. ... BIO Contest for the 2015 BIO International Convention. ... BIO International Convention will take place June 15-18 at ... Buzz of BIO contest, industry leaders will be voting ... the conference. The community voting period began on April ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3
Cached News: