HOME >> BIOLOGY >> NEWS
Non-toxic peptide blocks spread of prostate cancer in rats

ANN ARBOR---University of Michigan scientists have developed a new cancer-inhibiting peptide, or chain of amino acids, that has proven to be effective at preventing metastatic prostate cancer from spreading to other organs in laboratory rats. Rats treated systemically with the new peptide developed smaller primary tumors and fewer lung metastases than untreated rats and showed no toxic side effects from the treatment. The peptide was effective even if primary tumors were allowed to grow to a large size before surgery and peptide treatment began. If future studies show the peptide works as well in people, it could be the basis for a new approach to cancer therapy. In an article published in the Jan. 15 issue of Cancer Research, U-M scientists present results from an extensive series of experiments which document the peptide's ability to block cancer cells' invasive activity and limit the growth and spread of tumors in laboratory rats. U-M scientist Donna L. Livant, Ph.D., created the peptide by changing just one amino acid in a short sequence of a common blood protein called fibronectin, which circulates freely through the body in blood plasma, lymph, serum and interstitial fluid around cells. When tissue is damaged, fibronectin at the injury site fragments and diffuses outward. Unlike intact fibronectin, which is present everywhere in the body, these fragments bind to fibronectin receptors on cells surrounding damaged tissue, which stimulates them to invade and repair the injury. The downside to this process, according to Livant---an assistant professor of cellular biology in the U-M Medical School---is that cancer cells can mutate so that intact fibronectin stimulates them to invade surrounding tissue also. "Cancer is the price we pay for our ability to heal from wounds," Livant said. "When intact fibronectin stimulates cancer cells to invade, they can easily reach the blood or lymphatic system and metastasize or spread to other parts
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
(734)647-1844
University of Michigan
24-Jan-2000


Page: 1 2 3 4

Related biology news :

1. Study: Mothers turn fearless when peptide level drops
2. Infusion of two peptides acts to accelerate appetite satisfaction
3. Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles
4. Protease-inhibitor cocktail protects, increases anti-microbial action of promising new peptide
5. Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
6. Zengen, Inc. receives patent application approval for proprietary peptide technology
7. Scientists develop super peptide that kills Candida albicans
8. Patients with serious kidney disorder produce natriuretic peptides at above average rates
9. UB dental researchers find novel peptide in saliva that kills broad range of fungi and bacteria
10. Antimicrobial peptides: new weapons to fight infection
11. Regulation of vascular tone by a secreted mitochondrial peptide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/13/2017)... 13, 2017 Sandata Technologies, LLC, a ... homecare industry, including Electronic Visit Verification™ (EVV™), announced ... Jugs, as Senior Vice President of Product Management. ... of homecare experience to Sandata, where he will ... to align Sandata,s suite of solutions with the ...
(Date:1/11/2017)... , Jan. 11, 2017 Intoxalock, a ... with the release of its patent-pending calibration device. With ... reliably perform calibrations, securely upload data logs and process ... the customer. "Fighting drunk driving through the ... the public at large, but also for the customer ...
(Date:1/6/2017)...  Delta ID Inc., a leader in consumer-grade iris ... at CES® 2017. Delta ID has collaborated with Gentex ... use of iris scanning as a secure, reliable and ... a car, and as a way to elevate the ... Delta ID and Gentex will demonstrate (booth #7326 LVCC) ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017  An international team of ... and St. Boniface Hospital Albrechtsen Research Centre/University of ... an unmet health need affecting nearly one in ... Clinical Investigation, their results identify small molecule drugs ... reverse neuronal injury in animal models of metabolic, ...
(Date:1/17/2017)... , Jan. 17, 2017  Zimmer Biomet Holdings, Inc. ... and full-year 2016 sales and earnings conference call will ... 31, 2017, at 8 a.m. Eastern Time.  A news ... made available at 7:30 a.m. Eastern Time the morning ... webcast can be accessed via Zimmer Biomet,s Investor Relations ...
(Date:1/17/2017)... , Jan. 17, 2017 Noom ... is the first to offer fully Spanish behavior ... Noom,s Spanish diabetes prevention and healthy ... and accessibility of lifestyle interventions among Hispanic Americans ... conditions. Noom,s robust food database, program-specific curriculum content ...
(Date:1/17/2017)... Jan. 17, 2017  Only nine percent of U.S. ... profits, while only 16 percent believe health insurance companies ... Meanwhile, 36 percent of U.S. adults believe health care ... profits, compared to hospitals (23%). "We are ... Wendy Salomon , vice president of reputation management ...
Breaking Biology Technology:
Cached News: