HOME >> BIOLOGY >> NEWS
Non-toxic peptide blocks spread of prostate cancer in rats

ANN ARBOR---University of Michigan scientists have developed a new cancer-inhibiting peptide, or chain of amino acids, that has proven to be effective at preventing metastatic prostate cancer from spreading to other organs in laboratory rats. Rats treated systemically with the new peptide developed smaller primary tumors and fewer lung metastases than untreated rats and showed no toxic side effects from the treatment. The peptide was effective even if primary tumors were allowed to grow to a large size before surgery and peptide treatment began. If future studies show the peptide works as well in people, it could be the basis for a new approach to cancer therapy. In an article published in the Jan. 15 issue of Cancer Research, U-M scientists present results from an extensive series of experiments which document the peptide's ability to block cancer cells' invasive activity and limit the growth and spread of tumors in laboratory rats. U-M scientist Donna L. Livant, Ph.D., created the peptide by changing just one amino acid in a short sequence of a common blood protein called fibronectin, which circulates freely through the body in blood plasma, lymph, serum and interstitial fluid around cells. When tissue is damaged, fibronectin at the injury site fragments and diffuses outward. Unlike intact fibronectin, which is present everywhere in the body, these fragments bind to fibronectin receptors on cells surrounding damaged tissue, which stimulates them to invade and repair the injury. The downside to this process, according to Livant---an assistant professor of cellular biology in the U-M Medical School---is that cancer cells can mutate so that intact fibronectin stimulates them to invade surrounding tissue also. "Cancer is the price we pay for our ability to heal from wounds," Livant said. "When intact fibronectin stimulates cancer cells to invade, they can easily reach the blood or lymphatic system and metastasize or spread to other parts
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
(734)647-1844
University of Michigan
24-Jan-2000


Page: 1 2 3 4

Related biology news :

1. Study: Mothers turn fearless when peptide level drops
2. Infusion of two peptides acts to accelerate appetite satisfaction
3. Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles
4. Protease-inhibitor cocktail protects, increases anti-microbial action of promising new peptide
5. Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
6. Zengen, Inc. receives patent application approval for proprietary peptide technology
7. Scientists develop super peptide that kills Candida albicans
8. Patients with serious kidney disorder produce natriuretic peptides at above average rates
9. UB dental researchers find novel peptide in saliva that kills broad range of fungi and bacteria
10. Antimicrobial peptides: new weapons to fight infection
11. Regulation of vascular tone by a secreted mitochondrial peptide

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has ... Facial Recognition Market 2016-2020" report to ... has announced the addition of the ... to their offering. --> Research ... the addition of the "Global Facial ...
(Date:2/3/2016)... Sweden , February 4, 2016 --> ... amounted to SEK 1,351.5 M (105.0), up 1,187% compared with fourth quarter ... profit amounted to SEK 517.6 M (loss: 30.0). Earnings per ... operating activities was SEK 537.4 M (neg: 74.7). , ... , Revenues amounted to SEK 2,900.5 M (233.6), up 1,142% compared ...
(Date:2/3/2016)... 3, 2016 Vigilant Solutions announces today that ... Missouri solved two recent hit-and-run ... data from Vigilant Solutions. Brian Wenberg ... the victim was walking out of a convenience store and witnessed an elderly ... his vehicle, striking his vehicle and leaving the scene.  ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... -- The Maryland House of Delegates and House Speaker ... Maryland School of Medicine Dean E. Albert Reece ... System President and CEO Robert Chrencik , MBA, ... given to the public by the leader of the ... and Mr. Chrencik for their contributions to our statewide ...
(Date:2/10/2016)... Tarrytown, New York, and New York, New York (PRWEB) , ... ... ... Regeneron Pharmaceuticals Inc. (NASDAQ: REGN) today announced that ... discover and develop new vaccines and immunotherapies for infectious diseases and cancer. ...
(Date:2/10/2016)... 10, 2016  Matchbook, Inc., a company specializing ... biotech companies, announced today the appointment of ... Jim brings nearly 25 years of experience in ... spent nearly two decades in executive level roles ... at Genzyme and, most recently headed global logistics ...
(Date:2/10/2016)... ... , ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their new ... San Francisco’s Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS Expo ... PIN diode standard packages feature a TO-46 metal can with active areas of 1.0mm ...
Breaking Biology Technology:
Cached News: