HOME >> BIOLOGY >> NEWS
Northwestern program aims at revealing genetic causes of spina bifida

CHICAGO --- Johnny Doe (not his real name) is a little boy who is helping unravel a mystery for scientists at Northwestern University Medical School and Duke University.

Johnny was born with spina bifida, a common birth defect that deforms the spinal cord and which researchers believe may be linked to mutations in certain genes. Spina bifida affects about four of every 1,000 children born.

To assist in the search for these aberrant genes, Johnny and his parents and families like them contributed DNA samples to the Spina Bifida Genetic Research Project at Northwestern.

Program researchers are analyzing DNA samples from the Does and other families whose children have spina bifida to determine which genetic traits are found more often in these families and how these genes interact with each other and the environment. They also are conducting experiments to identify genes that may increase risk for spina bifida.

Jeffrey S. Nye, M.D., directs the program and is principal investigator on three National Institutes of Health-sponsored studies to determine the genetic basis of spina bifida. Nye, who also has a Ph.D., is an assistant professor of molecular pharmacology and biological chemistry and of pediatrics at the Medical School and at Childrens Memorial Hospital.

Numerous studies have implicated certain drugs, nutritional status (such as folic acid deficiency) and genetic factors in the development of spina bifida, yet scientists are still uncertain as to its actual cause.

Nye, with Northwestern co-investigators David G. McLone, M.D., Joel Charrow, M.D., John F. Sarwark, M.D., and Marcy Speer, Duke University, identified a number of common traits among families who have a child with spina bifida, such as deafness, areas of the hair and skin that lack pigmentation, early graying of the hair and deformities of the face and hands.

"For decades, researchers have known about the increased risk to families for having a second or third
'"/>

Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
22-Oct-2000


Page: 1 2

Related biology news :

1. Northwesterns Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent
2. Northwestern receives $5.65 million for reproductive research
3. New Northwestern center targets brain disorders
4. Northwestern launches major gene banking project
5. A little larceny comes naturally to Northwestern crows
6. Northwestern receives $17 million for functional genomics research
7. Northwestern researchers map gene mutation that makes mice deaf and causes them to dance
8. Northwestern scientists shed new light on neurodegenerative diseases
9. Northwestern researchers clone gene responsible for inner ear motor
10. Northwestern team identifies first enzyme in mammalian circadian clock
11. Northwestern Hosts Public Forum On Future Of Biotechnology

Post Your Comments:
(Date:10/14/2014)... prostate cancer tumors scavenge and hoard copper that is ... may be a fatal weakness. , Researchers at ... cancer cells by delivering a trove of copper along ... brimming with the mineral, leaving non-cancer cells healthy. , ... available for other uses, could soon be tested in ...
(Date:10/14/2014)... Ohio (Oct. 14, 2014)—It,s been millions of years since ... a team led by Ohio University scientists is breathing ... model airflow through dinosaur snouts. The research has important ... only breathe but to enhance the sense of smell ... ,nosy, animals," said Ohio University doctoral student Jason Bourke, ...
(Date:10/14/2014)... of the planet,s leading questions is how to produce ... variable climate. The Food and Agriculture Organization of the ... over the next 40 years to feed a growing ... the necessary rise in food production. Plants—grains, cereals, ... supporting livestock. Current research must tap into our ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market ... in Americas with analysis and forecast of revenue. ... Inorganic Refrigerants Market report, to get an idea ... a glimpse of the segmentation in the Americas ... tables and figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html ...
(Date:10/22/2014)... WriteResult, LLC – a premier provider of ... a team of researchers from Yale University’s School of ... to provide electronic questionnaire data collection through use of ... in May, aims to evaluate the impact of a ... and participation in urban agriculture to impact their consumption ...
(Date:10/22/2014)... According to new market research report ... Integration, Deployment & Support), by Service Model (SaaS, ... Others (Hybrid & Community)) - Global Forecast to ... Cloud Professional Services Market into various sub-segments with ... also identifies the drivers and restraints for this ...
(Date:10/22/2014)... , Oct. 22, 2014 Research ... "Organic Electronics Market by Material, by Application, Geography - ... to their offering. Organic electronics, also ... branch of material science which deals with small conductive ... organic because small molecules and polymers are carbon based, ...
Breaking Biology Technology:The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3
Cached News: