HOME >> BIOLOGY >> NEWS
Northwestern scientists shed new light on neurodegenerative diseases

EVANSTON, Ill. -In a breakthrough study to be published in the May 23 issue of the Proceedings of the National Academy of Sciences, scientists at Northwestern University report new insights into the biological and molecular underpinnings of an entire class of neurodegenerative diseases, ranging from Huntington's and Alzheimer's diseases to cystic fibrosis and Creutzfeldt-Jakob disease, the human form of mad cow disease.

The findings provide a new model for understanding the common pathology of these diseases, knowledge that could lead to the development of effective drugs.

The diseases, characterized by the loss of nerve function, are caused by a variety of mutant genes. However, they all have one element in common: misfolded proteins that lead to protein aggregation, the accumulation of insoluble proteins that can result in toxicity and disease.

In their study, Richard I. Morimoto, John Evans Professor of Biology, and his research team zeroed in on this commonality, focusing on the dangerous protein behavior itself instead of the genes responsible. They discovered that polyglutamine aggregates (one type of protein aggregate) are indeed toxic and that these unhealthy proteins bring healthy and otherwise normal proteins to aggregate with them. The researchers also found that the growth of these aggregates can be suppressed by molecular chaperones called heat shock proteins.

"This work highlights how basic science can answer important questions in terms of human neurodegenerative diseases," said Harry Orr, professor and director of the Institute of Human Genetics at the University of Minnesota Medical School. "Humans share much of the same biology with the subject of the study, the worm called C. elegans. The question that's being asked, whether a neuron lives or dies, is a fundamental one across species."

Proteins, made up of different combinations of amino acids, are basic components of all living cells. To do their job properly, e
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
21-May-2000


Page: 1 2 3 4

Related biology news :

1. Northwesterns Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent
2. Northwestern receives $5.65 million for reproductive research
3. New Northwestern center targets brain disorders
4. Northwestern launches major gene banking project
5. A little larceny comes naturally to Northwestern crows
6. Northwestern receives $17 million for functional genomics research
7. Northwestern program aims at revealing genetic causes of spina bifida
8. Northwestern researchers map gene mutation that makes mice deaf and causes them to dance
9. Northwestern researchers clone gene responsible for inner ear motor
10. Northwestern team identifies first enzyme in mammalian circadian clock
11. Northwestern Hosts Public Forum On Future Of Biotechnology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2017)... SAN FRANCISCO , Feb. 13, 2017 /PRNewswire/ ... a centralized platform that is designed to enhance ... the latest release in the RSA Fraud & ... to enable organizations to leverage additional insights from ... anti-fraud tools to better protect their customers from ...
(Date:2/9/2017)... , Feb. 9, 2017 The biomass ... analysis of the biomass boiler market globally in terms ... of biomass boilers. The market for biomass boilers has ... type, end-user, application, and country/region. The market based on ... & forest residues, biogas & energy crops, urban residues, ...
(Date:2/8/2017)... Report Highlights ... The global synthetic-biology market reached nearly $3.9 ... growing at a compound annual growth rate (CAGR) of 24.0% ... global markets for synthetic biology. - Analyses of global market ... of compound annual growth rates (CAGRs) through 2021. - Coverage ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017  In Atlanta, it seems everyone ... and culture intertwine to create an expressive and dynamic community ... this energy and contribute to it. With ... Hair Fairies seeks to carry on that tradition with ... Atlanta salon is the newest of 13 ...
(Date:2/23/2017)... INDIANAPOLIS, Ind. (PRWEB) , ... February 23, 2017 ... ... Commercialization Award during the 12th annual Inventors Recognition Reception at Purdue Research ... annually to a faculty member in recognition of outstanding contributions to, and success ...
(Date:2/23/2017)... and SAN FRANCISCO , ... privately-held regenerative medicine company, and Beyond Type 1, a ... type 1 diabetes, today announced a grant from Beyond ... functional cure for type 1 and other insulin-requiring diabetes.  ... has been developing innovative stem cell-derived cell replacement therapies ...
(Date:2/22/2017)... Feb. 22, 2017  PrimeVax Immuno-Oncology, Inc. announced today ... at the Annual Biocom Global Life Science Partnering Conference.  ... 11:15 AM, at the Torrey Pines Lodge, in San ... organizers at Biocom who have chosen our company, amongst ... biotechnology companies, investors, and clinical researchers," said Mr. Chen. ...
Breaking Biology Technology:
Cached News: