HOME >> BIOLOGY >> NEWS
Northwestern scientists shed new light on neurodegenerative diseases

EVANSTON, Ill. -In a breakthrough study to be published in the May 23 issue of the Proceedings of the National Academy of Sciences, scientists at Northwestern University report new insights into the biological and molecular underpinnings of an entire class of neurodegenerative diseases, ranging from Huntington's and Alzheimer's diseases to cystic fibrosis and Creutzfeldt-Jakob disease, the human form of mad cow disease.

The findings provide a new model for understanding the common pathology of these diseases, knowledge that could lead to the development of effective drugs.

The diseases, characterized by the loss of nerve function, are caused by a variety of mutant genes. However, they all have one element in common: misfolded proteins that lead to protein aggregation, the accumulation of insoluble proteins that can result in toxicity and disease.

In their study, Richard I. Morimoto, John Evans Professor of Biology, and his research team zeroed in on this commonality, focusing on the dangerous protein behavior itself instead of the genes responsible. They discovered that polyglutamine aggregates (one type of protein aggregate) are indeed toxic and that these unhealthy proteins bring healthy and otherwise normal proteins to aggregate with them. The researchers also found that the growth of these aggregates can be suppressed by molecular chaperones called heat shock proteins.

"This work highlights how basic science can answer important questions in terms of human neurodegenerative diseases," said Harry Orr, professor and director of the Institute of Human Genetics at the University of Minnesota Medical School. "Humans share much of the same biology with the subject of the study, the worm called C. elegans. The question that's being asked, whether a neuron lives or dies, is a fundamental one across species."

Proteins, made up of different combinations of amino acids, are basic components of all living cells. To do their job properly, e
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
21-May-2000


Page: 1 2 3 4

Related biology news :

1. Northwesterns Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent
2. Northwestern receives $5.65 million for reproductive research
3. New Northwestern center targets brain disorders
4. Northwestern launches major gene banking project
5. A little larceny comes naturally to Northwestern crows
6. Northwestern receives $17 million for functional genomics research
7. Northwestern program aims at revealing genetic causes of spina bifida
8. Northwestern researchers map gene mutation that makes mice deaf and causes them to dance
9. Northwestern researchers clone gene responsible for inner ear motor
10. Northwestern team identifies first enzyme in mammalian circadian clock
11. Northwestern Hosts Public Forum On Future Of Biotechnology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: