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Not all enlarged prostates are the same, say University of Pittsburgh researchers

ect in individuals with prostate cancer.

"Studying patterns of gene expression is a powerful tool. Already it is providing important clues about the fundamental nature of disease which will allow us to more strategically target our therapies," said Joel B. Nelson, M.D., professor and chairman of the department of urology at the University of Pittsburgh School of Medicine and co-director of the Comprehensive Prostate and Urologic Cancer Program at UPCI.

Further analysis showed that there were unique sets of genes that serve as a signature of each of the groups. Genes associated with cell proliferation were up regulated in the symptomatic BPH group. A series of genes including oncogenes were up regulated in the BPH cancer group. A cluster of genes with unknown function distinguished the asymptomatic BPH from the others.

One of the most striking of these discoveries is the strong correlation between inflammation and symptomatic BPH. With this information, we can now investigate new therapeutic approaches, such as using anti-inflammatory agents to alleviate symptoms. This is a key finding because previously, we were using a few drugs that were effective only in a small population and now, we may be able to stratify our treatments and diagnostics to better treat patients, said Dr. Getzenberg.

Subsets of genes including inflammatory mediators, cytokines and extracellular matrix associated molecules distinguished the symptomatic BPH and BPH with cancer from the normal and asymptomatic groups.

The study also found that JM27, a gene up regulated in prostate cancer and specific to the prostate and female reproductive tissues, was up regulated in symptomatic BPH, suggesting that overexpression of JM27 may be involved in the progression of BPH, prostate cancer and tumors of the female reproductive tract.

BPH is one of the most common diseases affecting men. More than half of all men over the age of 60, and 80 percent by age 80,
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Contact: Jocelyn Uhl
412-647-3555
University of Pittsburgh Medical Center
27-May-2002


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