HOME >> BIOLOGY >> NEWS
Novel COX-2 combination treatment may reduce colon cancer risk

Philadelphia, PA -- A combination of low-dose COX (cyclooxygenase)-2 inhibitors (celecoxib) and a biologically active component of fish oil (n-3 PUFAs, such as docosahexanoic acid, DHA) may prevent, and even treat, colon cancer, according to data published in the Proceedings for the 94th Annual Meeting of the American Association for Cancer Research (AACR). This effect of the low-dose combination regimen on human colon cancer cells was more pronounced than the use of each agent separately at high doses.

"Any medications taken at high doses may be accompanied by negative side effects, which may make them undesirable for the prevention and treatment of cancer," according to C.V. Rao, Ph.D., Associate Chief, Division of Nutritional Carcinogenesis, Institute For Cancer Prevention, American Health Foundation-Cancer Center, Valhalla, New York. "Therefore, we were pleased to see in our study that the combination treatment of COX-2 and fish oil component (DHA) was effective at tolerable doses."

In the study, human colon cancer cells were treated with several concentrations of celecoxib in combination with DHA, and either celecoxib or DHA alone. The study measured markers including cell growth, cell death, COX-2 expression and activity, and iNOS (inducible nitric oxide synthesis) expression. Results showed that celecoxib and/ or DHA inhibit cell growth and induce cell death at concentrations of >100 M

(micrometer) celecoxib and >150 M DHA in the human colon cancer cell line HCA-7. However, combining low-dose levels of celecoxib (50 M) and DHA (75 M) results in synergistic suppression of cell growth and also induces cell death in HCA-7 cells. Importantly, the key molecular targets of celecoxib and DHA, COX-2 expression and activity, are also synergistically suppressed by low-dose combinations of these agents.

Previous pre-clinical (animal) studies have demonstrated that the administration of fish oil alone reduces the risk of colon cancer by 60 to
'"/>

Contact: Aimee Frank
202-955-6222
American Association for Cancer Research
8-Apr-2003


Page: 1 2

Related biology news :

1. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
2. Novel therapeutic bortezomib moves to phase II trial in lung cancer patients
3. Novel approaches to current cellular therapies continue progress toward disease prevention
4. Novel therapies show promise against myeloid leukemia
5. Novel sensors help clear the air
6. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
7. Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
8. Novel therapeutic target identified in fight against Rheumatoid Arthritis
9. Novel bacterium detoxifies chlorinated pollutants
10. Novel flu vaccine shows promise in mice
11. Novel gene therapy on the horizon, says Brenner Childrens Hospital pediatrician

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... today announced that it has entered into a multi-year contract with Merus ... support their translational and clinical research strategy to discover and develop ground-breaking ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable ... testing operations in the fight against the COVID-19 pandemic in Zambia. , One ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and ... a strategic partnership whereby Catalent will provide support for the development, manufacturing, and ...
(Date:7/31/2020)... ... July 30, 2020 , ... Alucio™, ... announced the release of its signature product called Beacon - a content ... other field medical professionals. , Beacon helps MSLs streamline communication and ...
(Date:7/18/2020)... ... , ... “We are thrilled to deliver this new technology to the industry” ... kind on the market and we were pleased that the IFT jury recognized that.” ... ingredients, creating a natural way to extend the shelf life and improve the safety ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... announces a significant expansion of laboratory operations through its COVID-19 testing service, ... testing programs. , Bode-CARES provides a turnkey solution that includes ...
Breaking Biology Technology:
Cached News: