HOME >> BIOLOGY >> NEWS
Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting

Snowmass, Co. (September 9, 2004) Inflammatory Bowel Diseases, comprised of Crohn's Disease and ulcerative colitis, are for the most part incurable and their causes are still unknown. About 1 million Americans suffer from IBD and research around the world on new therapeutic strategies against IBD is being reported at a conference sponsored by the American Physiological Society.

Below are reports on three presentations.

  • Anti-adhesion therapy in the treatment of IBD Julian Panes and Josep M. Pique of the Gastroenterology Department of the Hospital Clinic Barcelona, Spain, note that the localization for leukocytes to inflammatory areas has key implications in the pathogenesis, diagnosis and treatment of IBD. A major effort has been directed toward identifying and characterizing the adhesion glycoproteins that enable leukocytes to bind to vascular endothelial cells. Drugs that specifically target adhesion molecules involved in leukocyte recruitment are effective in treating intestinal inflammation.

    They said that experimental models have shown that blockade of VLA-4, VCAM-1 and P-selectin afford significant amelioration of intestinal inflammation. In experimental models, response to adhesion molecule blockage varies according to the type of inflammatory intestinal condition. In humans VLA-4 immunoneutralization has been effective in inducing remission in Crohn's Disease, but no data is available for ulcerative colitis.

    The researchers call for experimental and clinical controlled trials comparing the effectiveness of different strategies of CAM blockade, and suggest that this therapeutic approach be compared with current therapies.

  • Platelet recruitment in intestinal inflammation modulated by ICAM-1, P-selectin, PSGL-1

    Researchers from LSU and the University of Muenster studied the mechanisms responsible for platelet-WBC and platelet-endothelial cell (EC) interactions that occur in exper
    '"/>



    • Contact: Mayer Resnick
    mresnick@the-aps.org
    301-634-7209
    American Physiological Society
    9-Sep-2004


    Page: 1 2 3

    Related biology news :

    1. Novel therapeutic bortezomib moves to phase II trial in lung cancer patients
    2. Novel approaches to current cellular therapies continue progress toward disease prevention
    3. Novel therapies show promise against myeloid leukemia
    4. Novel sensors help clear the air
    5. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
    6. Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
    7. Novel therapeutic target identified in fight against Rheumatoid Arthritis
    8. Novel bacterium detoxifies chlorinated pollutants
    9. Novel flu vaccine shows promise in mice
    10. Novel gene therapy on the horizon, says Brenner Childrens Hospital pediatrician
    11. Novel method identifies hidden genes

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its plans to ... and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. ... Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. , The ...
    (Date:6/6/2019)... ... June 05, 2019 , ... ... of a new network station and service center in Mexico City, Mexico. Mexico ... the world — with more than $1.75 billion in pharmaceutical exports since 2015. ...
    (Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG visualization platforms ... signals, usually based on variations of amplitude, frequency or spike train detection. In ... due to the complexity and variability of the signal, and automation tools are ...
    Breaking Biology News(10 mins):
    (Date:5/7/2019)... (PRWEB) , ... May 06, 2019 , ... ... go-to resource for the growing number of repositories being asked to store cellular ... grateful to the team of contributors who are world leaders, who have shared ...
    (Date:5/4/2019)... ... May 03, 2019 , ... ... the Diopsys® ffERG/Photopic Negative Response vision test, a new full field ... it is estimated that 6.3 million Americans will have glaucoma, with black Americans ...
    (Date:5/2/2019)... ... April 30, 2019 , ... The centuries old practice of brewing ... to local craft breweries, and even home brewing clubs scattered across the nation. ... processes, that when mastered can produce a superb product. Students at South Dakota ...
    (Date:5/2/2019)... ... May 02, 2019 , ... ... company, will present results documenting discrepancies between U.S. insurer policies for genetic testing ... at risk for hereditary breast and ovarian cancer (HBOC). , Jill ...
    Breaking Biology Technology:
    Cached News: