HOME >> BIOLOGY >> NEWS
Novel Method Of Gene Replacement Reported By University Of Washington Researchers

Dr. David W. Russell, assistant professor of medicine, and Roli Hirata, research technician at the University of Washington, report the successful use of a modified virus to perform a novel method of gene replacement that may be an important step toward overcoming obstacles to efficient gene therapy. Their findings are reported in the April issue of Nature Genetics.

Until now, gene therapy researchers have focused on gene addition, using a variety of modified viruses as vectors or transport vehicles to "infect" and insert the proper genetic material into cell nuclei that have genes with undesirable mutations. While the proper genetic material is inserted, it goes to random locations on the chromosome, and the faulty genetic material also remains.

By contrast, Russell and Hirata were able to achieve efficient gene correction. They succeeded in targeting the exact location of the mutated gene on the chromosome and replacing it with the correct genetic material present in the viral vector, at exactly the right location.

Russell uses a typewriter analogy: the new method finds the typographical error, whites it out and types in the proper sequence in the right place.

"If you had a 'typo' in a financial statement, say a missing zero, you'd want to fix in the right place, not randomly anywhere in the statement," he explains. "Or if you were correcting an instruction booklet with an error in it, you'd want to insert the corrected instruction in the right place on the right page."

The UW researchers' method guarantees that the new gene is controlled by appropriate genetic circuitry, ensuring that it is switched on in the right cells, at the right time and at the right dosage.

In addition to targeting exactly the right part of the cell, the repaired copy and the mutated copy of the genetic materal were exchanged at what researchers consider a very high frequency, in approximately 1 percent of ta
'"/>

Contact: Dr. David W. Russell
drussell@u.washington.edu
(206) 616-4562
University of Washington
30-Mar-1998


Page: 1 2

Related biology news :

1. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
2. Novel therapeutic bortezomib moves to phase II trial in lung cancer patients
3. Novel approaches to current cellular therapies continue progress toward disease prevention
4. Novel therapies show promise against myeloid leukemia
5. Novel sensors help clear the air
6. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
7. Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
8. Novel therapeutic target identified in fight against Rheumatoid Arthritis
9. Novel bacterium detoxifies chlorinated pollutants
10. Novel flu vaccine shows promise in mice
11. Novel gene therapy on the horizon, says Brenner Childrens Hospital pediatrician

Post Your Comments:
(Date:8/25/2014)... the first U.S. outbreaks of the H1N1 virus swept ... people. A university math and biology professor has used ... gain insight into how only a few infected people ... community., The fall 2009 semester hadn,t even started when ... and Wellness Services clinic11 one day, and just two ...
(Date:8/25/2014)... battery-powered DNA diagnostic device invented at New Zealand,s ... commonly used field tool for rapidly detecting suspected ... the level of infection. , The breakthrough device, ... Queenstown Molecular Biology main meeting. It takes advantage ... target DNA sequences in real-time, without the need ...
(Date:8/25/2014)... separation from a device the size of a cell ... acoustic waves, according to a team of engineers., "For ... before analysis," said Tony Jun Huang, professor of engineering ... the integrity of the cells, damages them in any ... surface acoustic waves can separate cells using very small ...
Breaking Biology News(10 mins):WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3Revolutionary handheld DNA diagnostic unit allows lab-quality analysis in the field 2Tilted acoustic tweezers separate cells gently 2
(Date:8/26/2014)... , Aug. 26, 2014  That,s Nice LLC, ... markets, today announced the formation of a new dedicated ... development. The expanded team will combine current and new ... at That,s Nice. Guy Tiene ... to lead the team. Tiene was previously Director of ...
(Date:8/26/2014)... InstantGMP, Inc., the only cloud-based manufacturing execution ... structure with increased user accounts to help current and ... Part 11 requirements. , “We want to help our ... said Rick Soltero, President of InstantGMP. “We found ... to have separate accounts for multiple quality managers and ...
(Date:8/26/2014)... August 26, 2014 Formedix, the ... announced the release of Transform for MARVIN: the ... Data Capture (EDC) product line. It was developed ... allows integration with MARVIN, the EDC and Clinical ... study setup time, by allowing instantaneous visualization of ...
(Date:8/26/2014)... 2014 /PRNewswire-iReach/ -- The crowdfunding campaign for PosturePulse ... on the popular crowdfunding platform Kickstarter. Backers have already ... biofeedback belt. The $75,000 funding goal for the campaign ... product. Photo - http://photos.prnewswire.com/prnh/20140825/139254 ... the lower back that silently vibrates if the wearer ...
Breaking Biology Technology:That's Nice Announces Expanded Offering For Strategic Content And Public Relations 2That's Nice Announces Expanded Offering For Strategic Content And Public Relations 3Introducing Transform for MARVIN: Providing Further Flexibility for CROs and Sponsors in Partnership with XClinical 2PosturePulse, A Biofeedback Posture-Improving Belt, Improves Posture While Sitting or Standing 2
Cached News: