HOME >> BIOLOGY >> NEWS
Novel Method Of Gene Replacement Reported By University Of Washington Researchers

Dr. David W. Russell, assistant professor of medicine, and Roli Hirata, research technician at the University of Washington, report the successful use of a modified virus to perform a novel method of gene replacement that may be an important step toward overcoming obstacles to efficient gene therapy. Their findings are reported in the April issue of Nature Genetics.

Until now, gene therapy researchers have focused on gene addition, using a variety of modified viruses as vectors or transport vehicles to "infect" and insert the proper genetic material into cell nuclei that have genes with undesirable mutations. While the proper genetic material is inserted, it goes to random locations on the chromosome, and the faulty genetic material also remains.

By contrast, Russell and Hirata were able to achieve efficient gene correction. They succeeded in targeting the exact location of the mutated gene on the chromosome and replacing it with the correct genetic material present in the viral vector, at exactly the right location.

Russell uses a typewriter analogy: the new method finds the typographical error, whites it out and types in the proper sequence in the right place.

"If you had a 'typo' in a financial statement, say a missing zero, you'd want to fix in the right place, not randomly anywhere in the statement," he explains. "Or if you were correcting an instruction booklet with an error in it, you'd want to insert the corrected instruction in the right place on the right page."

The UW researchers' method guarantees that the new gene is controlled by appropriate genetic circuitry, ensuring that it is switched on in the right cells, at the right time and at the right dosage.

In addition to targeting exactly the right part of the cell, the repaired copy and the mutated copy of the genetic materal were exchanged at what researchers consider a very high frequency, in approximately 1 percent of ta
'"/>

Contact: Dr. David W. Russell
drussell@u.washington.edu
(206) 616-4562
University of Washington
30-Mar-1998


Page: 1 2

Related biology news :

1. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
2. Novel therapeutic bortezomib moves to phase II trial in lung cancer patients
3. Novel approaches to current cellular therapies continue progress toward disease prevention
4. Novel therapies show promise against myeloid leukemia
5. Novel sensors help clear the air
6. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
7. Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
8. Novel therapeutic target identified in fight against Rheumatoid Arthritis
9. Novel bacterium detoxifies chlorinated pollutants
10. Novel flu vaccine shows promise in mice
11. Novel gene therapy on the horizon, says Brenner Childrens Hospital pediatrician

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... first-ever genomics analysis platform specifically designed for life science researchers to analyze ... pioneering researcher Rosalind Franklin, who made a major contribution to the discovery ...
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... set to take place on 7th and 8th June 2018 in San Francisco, CA. ... policy influencers as well as several distinguished CEOs, board directors and government officials from ...
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
Breaking Biology Technology:
Cached News: