HOME >> BIOLOGY >> NEWS
Novel method identifies 'hidden' genes

Cambridge, Mass. (April 16, 2003)--Once thought to serve only as a bridge between genes and protein production, RNA is quickly shedding its reputation as being all brawn and no brain. RNA's research renaissance is due in part to the recent discovery of a new class of genes called microRNAs (miRNAs). Rather than code for proteins, miRNAs serve as regulators--genetic trump cards that turn protein-coding genes off.

Scientists announced this week the development of a new computational method that provides a reliable way to estimate the total number of miRNA genes in different animals. The researchers used the tool to help identify 88 miRNA genes in the worm C. elegans, a model system important in the study of human genetics. They also estimate that miRNA genes comprise nearly one percent of the human genome, making miRNA genes one of the more abundant types of regulatory genes in humans. The next step, say researchers, is to investigate the roles they play in cell growth and development.

This work, from David Bartel's lab at the Whitehead Institute for Biomedical Research and Christopher Burge's lab at MIT, was published in the April 13 issue of Genes and Development.

"MicroRNAs have been controlling the regulation of other genes for a very long time," said Bartel. "Having this extra layer of gene regulation may have enabled the emergence of the multicellular body plans found in both plants and animals. The developmental processes that give rise to an adult plant or animal require a lot of turning on and off of genes."

For many years, miRNAs went undetected because they do not code for proteins--the benchmark traditionally used to define genes within a genome. Interest in RNA as a gene regulator began when researchers first discovered two small RNAs that impacted the translation of genes into proteins in worms. If these RNAs were missing, a worm's development stalled before it reached maturity.

These findings inspired research
'"/>

Contact: Kelli Whitlock or Melissa Withers
newsroom@wi.mit.edu
617-258-5183
Whitehead Institute for Biomedical Research
17-Apr-2003


Page: 1 2 3

Related biology news :

1. Novel IBD therapeutic approaches reported from Washington Univ., Barcelona, LSU at APS meeting
2. Novel therapeutic bortezomib moves to phase II trial in lung cancer patients
3. Novel approaches to current cellular therapies continue progress toward disease prevention
4. Novel therapies show promise against myeloid leukemia
5. Novel sensors help clear the air
6. Fox Chase Cancer Center study: Novel DNA-repair gene mutation can cause resistance to cancer drugs
7. Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
8. Novel therapeutic target identified in fight against Rheumatoid Arthritis
9. Novel bacterium detoxifies chlorinated pollutants
10. Novel flu vaccine shows promise in mice
11. Novel gene therapy on the horizon, says Brenner Childrens Hospital pediatrician

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/16/2019)... , ... April 16, 2019 , ... ... 50 Healthcare Technology CEOs of 2019 . An extensive process was run to ... medical devices, biotech, healthcare analytics, healthcare software and other related areas. We gathered ...
(Date:4/12/2019)... ... April 12, 2019 , ... Gnubiotics Sciences SA ... accessible carbohydrates (MACs) as specialty ingredients for the global animal and human nutrition ... commercial launch of its first-in class microbiome modulating prebiotic GNU100, for companion animal ...
(Date:4/4/2019)... ... 02, 2019 , ... Catalent Pharma Solutions, the leading global ... health products, today announced that it will host a roundtable session at the ... Oxon Hill, Maryland, on April 10-12, 2019. , On Thursday, April 11 at ...
Breaking Biology News(10 mins):
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a ... million bench plant expansion to increase production of methylene malonate monomers and oligomers. ... construction of Sirrus’ full-scale production facility, which is scheduled to break ground in ...
(Date:4/9/2019)... POWAY, Calif. (PRWEB) , ... April 09, 2019 , ... ... on his left front limb for approximately two months. After a series of ... digital flexor tendon. Sonny’s owner, Alison, researched the injury and found that ...
(Date:4/4/2019)... ... April 02, 2019 , ... Biomeme, Inc. ... releasing it’s latest field-ready solution for performing PCR, RT-PCR, qPCR, and Isothermal tests ... homage to Rosland Franklin, an English chemist and X-ray crystallographer who made significant ...
(Date:3/27/2019)... , ... March 27, 2019 , ... Lachman is sponsoring ... the Clayton Hotel Burlington Road, Dublin, Ireland. The executive team on site will be ... 4.0, two key tracks on the agenda this year. , Executives from Lachman participating ...
Breaking Biology Technology:
Cached News: