Novel therapies show promise against myeloi...( phase. As patients move through these ...)

Novel therapies show promise against myeloid leukemia

phase. As patients move through these phases, the prognosis worsens and patients experience increasing physical symptoms. Patients with poor cytogenetic assessments or with progression before the respective time point were not included.

"In addition to these results, the effect of increasing the dose of imatinib on the probability of attaining a major or complete response is being analyzed," said Brian Druker, M.D., of the Oregon Health & Science University Cancer Institute, the Howard Hughes Medical Institute, and lead author of the study. "We hope to confirm the reliability of cytogenetic responses and progression-free survival in patients developing major and complete responses with this therapy."

Leukemia is a cancer of the blood and the bone marrow in which certain blood cells become abnormal, yet the body continues to produce large numbers of these abnormal cells. Chronic myelogenous leukemia, or CML, is one type, referring to long-term cancer in which the body overproduces cancerous myeloid white blood cells.

Mesenchymal Progenitor Cells as Gene Delivery Systems for Cancer and Leukemia Therapy (Abstract 201)

Unlike hematopoietic (blood forming) stem cells, bone marrow-derived mesenchymal progenitor cells, or stem cells (MSC), can be intravenously injected into patients with leukemias and solid tumors without rejection. Scientists from The University of Texas M.D. Anderson Cancer Center explored the potential of human MSC to carry therapeutic genes into tumors and examined whether MSC producing interferon-beta can inhibit the growth of metastatic tumors in the lungs of immunodeficient mice. The interferon was produced by MSC after their infection with a virus carrying the interferon-beta gene. Immunodeficient mice are used for transplantation and the study of human cancers and leukemias.

Upon infecting MSC with interferon-beta
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Contact: Aimee Frank
amf@spectrumscience.com
202-955-6222
American Society of Hematology
6-Dec-2003

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