HOME >> BIOLOGY >> NEWS
OHSU team discovers compound that lacks estrogen's risks

and Rnnekleiv.

STX appears to act by stimulating a novel estrogen receptor, located in the cell membrane, that activates proteins involved in rapid cell signaling. In this way, it avoids the uterus and breasts, whose growth is stimulated by estrogen through a different pathway, leading to increased cancer risk.

The hypothalamus "controls all autonomic functions and maintains homeostasis eating, drinking, sex behavior, maternal and even paternal behavior," Kelly said. In particular, hypothalamic POMC neurons, which are especially sensitive to STX, "are what activate the natural reward pathways. This is the brain's endogenous opiate system."

Having a selective estrogen trigger for rapid signaling is critical for estrogen replacement therapy, Kelly said. STX is structurally distinct from tamoxifen and raloxifene, and it's about 10 times more potent than estrogen and has the potential to be more effective at maintaining cognitive performance of postmenopausal women.

"Women that don't have hormone replacement therapy have been known to have more cognitive impairment in terms of loss of memory, and a higher incidence of Alzheimer's disease," Kelly said. "At least at the basic level, existing SERMs do not seem to help. So the search was on for other compounds one can use to replace tamoxifen. The collaboration with Dr. Scanlan at UCSF made it possible to synthesize and test a series of related compounds before we came up with STX."

Despite the discovery of STX, Rnnekleiv stopped short of rejecting estrogen as an effective therapy, saying its many benefits far outweigh the risks that studies have yet to unequivocally demonstrate.

"Estrogen definitely has neuroprotective effects in the brain," Rnnekleiv said. "At least in animal models, it's been shown that estrogen can reduce neuronal cell death from stroke. One of the other important actions of estrogen is to prevent osteoporosis."

Kelly's and Rnnekle
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
30-Dec-2003


Page: 1 2 3

Related biology news :

1. LSU researcher discovers new bird
2. MIT team discovers memory mechanism
3. SMCM professor discovers cattle hormones that leak into streams and alter fish reproduction
4. UBC researcher discovers control room that regulates immune responses
5. UC Santa Barbara discovers cell survival gene may lead to treatments for degenerative diseases
6. Brain patterns the same whether doing or just watching, Queens researcher discovers
7. Study discovers key to baby-like skin
8. Rutgers researcher discovers melanoma causing gene
9. UI study discovers cells segregate molecules to control signaling
10. Polluted beach closures influenced by full moons and sunlight, surfer-engineer discovers
11. University of Pittsburgh Cancer Institute discovers proteins linked to colon cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:7/24/2017)... Lawrence, MA (PRWEB) , ... July 24, 2017 , ... ... (TET-SL) has been accepted by the National Conference on Interstate Milk Shipments (NCIMS) Laboratory ... its Pilot Program, set to launch July 1, 2017. , The NCIMS voted at ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... today announced that the stock market news outlet had initiated coverage on ... testing that screens and identifies exposure, progression and risk analysis from specific ...
(Date:7/20/2017)... , ... July 20, 2017 , ... Dr. Asher Kimchi, ... winning recipients of the 2017 IAC Awards at the 22nd World Congress on Heart ... also named four faculty to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, ...
(Date:7/20/2017)... ... July 20, 2017 , ... Corista, a leader in ... intelligence Tuesday, July 25, during the Association of Pathology Chairs’ Jubilee Meeting in ... , Baras, Associate Director of Pathology Informatics, will present “The Digital Pathology Experience ...
Breaking Biology Technology:
Cached News: