HOME >> BIOLOGY >> NEWS
OHSU team discovers compound that lacks estrogen's risks

and Rnnekleiv.

STX appears to act by stimulating a novel estrogen receptor, located in the cell membrane, that activates proteins involved in rapid cell signaling. In this way, it avoids the uterus and breasts, whose growth is stimulated by estrogen through a different pathway, leading to increased cancer risk.

The hypothalamus "controls all autonomic functions and maintains homeostasis eating, drinking, sex behavior, maternal and even paternal behavior," Kelly said. In particular, hypothalamic POMC neurons, which are especially sensitive to STX, "are what activate the natural reward pathways. This is the brain's endogenous opiate system."

Having a selective estrogen trigger for rapid signaling is critical for estrogen replacement therapy, Kelly said. STX is structurally distinct from tamoxifen and raloxifene, and it's about 10 times more potent than estrogen and has the potential to be more effective at maintaining cognitive performance of postmenopausal women.

"Women that don't have hormone replacement therapy have been known to have more cognitive impairment in terms of loss of memory, and a higher incidence of Alzheimer's disease," Kelly said. "At least at the basic level, existing SERMs do not seem to help. So the search was on for other compounds one can use to replace tamoxifen. The collaboration with Dr. Scanlan at UCSF made it possible to synthesize and test a series of related compounds before we came up with STX."

Despite the discovery of STX, Rnnekleiv stopped short of rejecting estrogen as an effective therapy, saying its many benefits far outweigh the risks that studies have yet to unequivocally demonstrate.

"Estrogen definitely has neuroprotective effects in the brain," Rnnekleiv said. "At least in animal models, it's been shown that estrogen can reduce neuronal cell death from stroke. One of the other important actions of estrogen is to prevent osteoporosis."

Kelly's and Rnnekle
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
30-Dec-2003


Page: 1 2 3

Related biology news :

1. LSU researcher discovers new bird
2. MIT team discovers memory mechanism
3. SMCM professor discovers cattle hormones that leak into streams and alter fish reproduction
4. UBC researcher discovers control room that regulates immune responses
5. UC Santa Barbara discovers cell survival gene may lead to treatments for degenerative diseases
6. Brain patterns the same whether doing or just watching, Queens researcher discovers
7. Study discovers key to baby-like skin
8. Rutgers researcher discovers melanoma causing gene
9. UI study discovers cells segregate molecules to control signaling
10. Polluted beach closures influenced by full moons and sunlight, surfer-engineer discovers
11. University of Pittsburgh Cancer Institute discovers proteins linked to colon cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: OHSU team discovers compound that lacks estrogen risks

(Date:4/22/2014)... in two Minnesota cities demonstrate how communities can ... a ten year program in New England and ... to local conditions. , "Our goal is to ... said program co-leader Latham Stack, of Syntectic International, ... worsened. We help communities move beyond feeling paralyzed ...
(Date:4/21/2014)... is commonly used as a farm soil fertilizer, contains ... from the cows, gut bacteria. The findings, reported in ... American Society for Microbiology, hints that cow manure is ... genes that transfer to bacteria in the soils where ... (AR) genes have already been identified, but the vast ...
(Date:4/21/2014)... are on the decline in the Galpagos. , A new ... indicates numbers of the iconic birds, known for their ... attract mates, have fallen more than 50 percent in less ... is probably due to an unexplained disappearance of sardines from ... at Wake Forest University and the study,s principal investigator. This ...
Breaking Biology News(10 mins):Minnesota projects offer hope and practical help to communities facing more extreme storms 2Cow manure harbors diverse new antibiotic resistance genes 2Cow manure harbors diverse new antibiotic resistance genes 3Lack of breeding threatens blue-footed boobies' survival 2Lack of breeding threatens blue-footed boobies' survival 3
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to announce that ... an e-Journal and producer of Food Labs Conference ... for the co-location of Food Labs Conference to be held ... registration fee to attend the two-day Food Lab Conference, March ...
(Date:1/15/2014)... 2014 Look inside the new Preferred ... the lab, from fluid handling to instruments to supplies. ... when you order. , Preferred Solutions features a ... the L/S® model for precise flow control and dispensing ...
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2
Cached News: