HOME >> BIOLOGY >> NEWS
OHSU team discovers compound that lacks estrogen's risks

and Rnnekleiv.

STX appears to act by stimulating a novel estrogen receptor, located in the cell membrane, that activates proteins involved in rapid cell signaling. In this way, it avoids the uterus and breasts, whose growth is stimulated by estrogen through a different pathway, leading to increased cancer risk.

The hypothalamus "controls all autonomic functions and maintains homeostasis eating, drinking, sex behavior, maternal and even paternal behavior," Kelly said. In particular, hypothalamic POMC neurons, which are especially sensitive to STX, "are what activate the natural reward pathways. This is the brain's endogenous opiate system."

Having a selective estrogen trigger for rapid signaling is critical for estrogen replacement therapy, Kelly said. STX is structurally distinct from tamoxifen and raloxifene, and it's about 10 times more potent than estrogen and has the potential to be more effective at maintaining cognitive performance of postmenopausal women.

"Women that don't have hormone replacement therapy have been known to have more cognitive impairment in terms of loss of memory, and a higher incidence of Alzheimer's disease," Kelly said. "At least at the basic level, existing SERMs do not seem to help. So the search was on for other compounds one can use to replace tamoxifen. The collaboration with Dr. Scanlan at UCSF made it possible to synthesize and test a series of related compounds before we came up with STX."

Despite the discovery of STX, Rnnekleiv stopped short of rejecting estrogen as an effective therapy, saying its many benefits far outweigh the risks that studies have yet to unequivocally demonstrate.

"Estrogen definitely has neuroprotective effects in the brain," Rnnekleiv said. "At least in animal models, it's been shown that estrogen can reduce neuronal cell death from stroke. One of the other important actions of estrogen is to prevent osteoporosis."

Kelly's and Rnnekle
'"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
30-Dec-2003


Page: 1 2 3

Related biology news :

1. LSU researcher discovers new bird
2. MIT team discovers memory mechanism
3. SMCM professor discovers cattle hormones that leak into streams and alter fish reproduction
4. UBC researcher discovers control room that regulates immune responses
5. UC Santa Barbara discovers cell survival gene may lead to treatments for degenerative diseases
6. Brain patterns the same whether doing or just watching, Queens researcher discovers
7. Study discovers key to baby-like skin
8. Rutgers researcher discovers melanoma causing gene
9. UI study discovers cells segregate molecules to control signaling
10. Polluted beach closures influenced by full moons and sunlight, surfer-engineer discovers
11. University of Pittsburgh Cancer Institute discovers proteins linked to colon cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: OHSU team discovers compound that lacks estrogen risks

(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report ... markets for Hand Geometry in US$ Thousands. The report provides ... , Japan , Europe ... , and Rest of World. Annual estimates ...
(Date:3/19/2015)... , March 19, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces its ... a news clip that aired this week on ... . In a segment "The Next Great Thing", ... ,a new way to pay, and ,a really big breakthrough ...
(Date:3/17/2015)... March 17, 2015 Emotient, the leader ... today announced general availability of Emotient Analytics ... the analysis of facial expressions. The system analyzes ... content, products and services. It delivers audience response ... sentiment - as derived from facial evidence of ...
Breaking Biology News(10 mins):Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
(Date:4/24/2015)... (PRWEB) April 24, 2015 Leading ... milestones in its allogeneic stem-cell product development program ... properly reflect the corporate strategic direction. , “I ... (donor) adipose stem cell development program has been ... our cGMP manufacturing facility and hiring of our ...
(Date:4/24/2015)... April 24, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... as the supplier of bio-succinic acid used to ... for textile applications that Bayer MaterialScience has begun ... IMPRANIL ® eco, a series of bio-based ... as high as 65%.  IMPRANIL ® eco ...
(Date:4/24/2015)... - Mirego, leader in mobile strategies and solutions, is proud ... extensions for the all new Apple Watch. Made in ... MediaMiser, these extensions will reinvent the way users receive and ... use.  Available today in Canada ... smartwatch that makes for an excellent buddy for business, health ...
(Date:4/24/2015)... 2015 PAREXEL International Corporation (NASDAQ: ... announced that Partnerships in Clinical Trials named PAREXEL,s ... Clinical Innovator of the Year.  The honor recognizes Mr. ... Company,s Perceptive MyTrials ® Data-Driven Monitoring solution. ... the 2015 Partnership Awards in Boston ...
Breaking Biology Technology:Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5
Cached News: