HOME >> BIOLOGY >> NEWS
Obesity Gene: Possible Link To Heart Disease Risk

DALLAS, June 12 -- A link has been found between leptin, a protein product of the obesity gene, and risk for coronary heart disease, the cause of heart attacks, say researchers in a study published today in an American Heart Association journal.

The obesity gene was cloned in 1994. Its product, leptin, acts as a signal to help the body decide when it has eaten enough food to feel full. The amount of leptin in the blood has been directly linked to body fat.

This study is the first to associate leptin elevations in the blood with so-called insulin resistance syndrome. The syndrome -- characterized by high blood pressure, low levels of the "good" high-density lipoprotein cholesterol and elevations in insulin -- sets the stage for heart disease. Insulin is a hormone that helps the body use glucose, its main fuel. An excess of insulin (a condition called insulin resistance) indicates the body is not processing glucose normally.

The study was conducted by researchers in the Wynn department of metabolic medicine of the Imperial College School of Medicine, London.

In the study, which appears in Arteriosclerosis, Thrombosis and Vascular Biology: Journal of the American Heart Association, researchers measured blood leptin levels in 74 men. They found that the higher the level of leptin the more likely the men were to have the syndrome, and thus "perhaps a greater heart disease risk," says Francisco Leyva, M.D., specialist registrar in cardiology at Charing Cross Hospital.

"We have found that leptin concentrations are related to the metabolic disturbances that constitute the syndrome, especially insulin resistance," says Leyva. "Futher studies are needed to determine whether insulin and leptin play a coordinating role in this syndrome and whether leptin concentrations could provide an additional measure of heart risk.

"Measuring leptin might become a new way to determine a person's risk of heart dis
'"/>

Contact: Carole Bullock
caroleb@amhrt.org
214-706-1279
American Heart Association
11-Jun-1998


Page: 1 2

Related biology news :

1. Obesity and hypertension: Two epidemics or one?
2. Obesity alone not a good predictor of cardiovascular risk and death, fat distribution proved best
3. Obesity drug inhibits prostate tumor growth
4. Obesity and blood pressure
5. Obesity, kidney genetics, erectile dysfunction among highlighted research at APS Meeting
6. Obesity in Costa Rican children alarming, likely future health burden
7. Obesity prevention program aimed at second graders
8. Obesity not a personal failing, but a battle against biology
9. Obesity sleuths find chronic diseases linked to behavior contrary our DNA
10. Obesity...by choice
11. Obesity may exacerbate a heart disorder in African American females

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Obesity Gene Possible Link Heart Disease Risk

(Date:4/17/2014)... hydrogen sulfide in order to properly multiply and form ... Center for Craniofacial Molecular Biology at the Herman Ostrow ... principal investigator on the project, said the presence of ... of calcium ions. The essential ions activate a chain ... creation of new bone tissue, and keeps the breakdown ...
(Date:4/17/2014)... in German . ... money demanded of him, he can expect his premises to ... fear of the consequences is enough to make restaurant owners ... which lay their eggs in other birds, nests. If the ... take their revenge by destroying the entire nest. Consequently, it ...
(Date:4/17/2014)... France have hit on a novel method to ... correct and most effective treatment possible., Kidney stones ... and developing world. If left untreated, apart from ... failure and other complications. In many patients treated ... a more effective pathological approach to diagnosis and ...
Breaking Biology News(10 mins):Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... BURLINGAME, Calif. , Jan. 14, 2014 As pet owners ... no doubt many of them wrote: "Take better care of my ... and even designer clothes and top-brand carrying cases to take the ... Pet parents might also feel compelled to buy some pricey toys ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
Cached News: