HOME >> BIOLOGY >> NEWS
'Obesity gene' causes cancer of fat tissue, Schepens scientists find

A gene previously identified as important in promoting obesity also appears to be responsible for causing a common human tumor, researchers at The Schepens Eye Research Institute have found.

The gene, known as HMG I-C, causes tumors called lipomas, a common tumor in fat tissue in humans. Lipomas start as benign growths, but can become malignant liposarcomas as they grow. Lipomas are the most common form of mesenchymal tumors found in humans.

"There is now strong evidence that targeting this molecule may be useful both for the treatment of obesity in humans and the treatment of lipomas. It is likely that therapeutic agents which block the expression of the HMG I-C would be effective in the treatment of these two major clinical problems ," said Santa J. Ono, Ph.D., Associate Scientist at The Schepens Eye Research Institute and Associate Professor at Harvard Medical School.

Ono and his colleagues report their findings in The Journal of Biological Chemistry, scheduled for publication on May 12, 2000. The paper has been online at the journal's web site (www.jbc.org) since March 15. Coauthors are Paola Arlotta, Ph.D., and Albert K.-F. Tai, both of The Schepens Eye Research Institute; Guidalberto Manfioletti, Ph.D., University of Trieste, Italy; Charles Clifford, Ph.D., Charles Rivers Laboratories, Wilmington, Mass.; and Gilbert Jay, Ph.D., OriGene Technologies, Rockville, Md.

Previous epidemiologic data had shown that the HMG I-C gene is defective in many mesenchymal tumors. The Ono team has proven a direct role for the HMG I-C gene in lipoma formation by creating transgenic mouse lines that overexpress the defective HMG I-C gene in all cells of the body. The transgenic mice are obese early in life and develop tumors of the adipose (fat) tissue in adult life. About 25 percent of the transgenic mice develop tumors, while control mice, or normal mice, showed no evidence of tumor formation.

The researchers also found that no tumors formed in o
'"/>

Contact: Larry Bernard
bernard@vision.eri.harvard.edu
617-912-2548
Schepens Eye Research Institute
25-Apr-2000


Page: 1 2

Related biology news :

1. Obesity sleuths find chronic diseases linked to behavior contrary our DNA
2. New clock gene uncovered
3. Super-effective jumping gene created
4. Scripps Research scientists find deafness genes function
5. Ageing gene could be passed on via X chromosome
6. Role in Type 1 diabetes provides clue for researchers who discovered obesity gene
7. Discovery of how prolactin travels to genes machinery helps explain its role in breast cancer
8. Mighty mice are less susceptible to muscular dystrophy genes effects
9. New cholesterol disorder discovered As predicted from genes role
10. Investigating a protective gene against alcoholism
11. Scientists at UCLAs Jonsson Cancer Center discover genes role in regulating stem cells in the brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... , March 20, 2017 PMD Healthcare ... personal spirometer and Wellness Management System (WMS), a remote, ... Founded in 2010, PMD Healthcare is a Medical Device, ... a mission dedicated to creating innovative solutions that empower ... With that intent focus, PMD developed the first ever ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
(Date:3/7/2017)... 7, 2017   HireVue , the leading provider ... identify the best talent, faster, today announced the additions ... (CSO) and Diana Kucer as Chief Marketing ... executive team poised to drive continued growth in the ... year of record bookings in 2017. "Companies ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... ... secure electronic informed consent (eConsent) solution that simplifies research studies, accelerates study startup, ... division of Quorum, Q Consent™ is the first and only IRB-integrated eConsent ...
(Date:4/27/2017)... New Orleans, La. (PRWEB) , ... ... ... Polymer Monitoring Technologies today announced a comprehensive rebrand and a name change ... products for the industrial and laboratory monitoring of polymer and biopharmaceutical manufacturing ...
(Date:4/27/2017)... , April 27, 2017  Kinexum, a distinguished ... products, today announces the appointment of Thomas C. ... Alexander ("Zan") Fleming, M.D., Kinexum founder, who becomes Executive ... advisor to Kinexum clients. Thomas Seoh ... on the Kinexum mission and lead the firm,s remarkable ...
(Date:4/26/2017)... , ... April 25, 2017 , ... LABS, Inc. (LABS) ... were added to its extensive test menu: Nucleic Acid Testing (NAT) for ZIKV; and ... was only able to offer NAT screening for blood donors under an Investigational New ...
Breaking Biology Technology:
Cached News: