HOME >> BIOLOGY >> NEWS
'Obesity gene' causes cancer of fat tissue, Schepens scientists find

A gene previously identified as important in promoting obesity also appears to be responsible for causing a common human tumor, researchers at The Schepens Eye Research Institute have found.

The gene, known as HMG I-C, causes tumors called lipomas, a common tumor in fat tissue in humans. Lipomas start as benign growths, but can become malignant liposarcomas as they grow. Lipomas are the most common form of mesenchymal tumors found in humans.

"There is now strong evidence that targeting this molecule may be useful both for the treatment of obesity in humans and the treatment of lipomas. It is likely that therapeutic agents which block the expression of the HMG I-C would be effective in the treatment of these two major clinical problems ," said Santa J. Ono, Ph.D., Associate Scientist at The Schepens Eye Research Institute and Associate Professor at Harvard Medical School.

Ono and his colleagues report their findings in The Journal of Biological Chemistry, scheduled for publication on May 12, 2000. The paper has been online at the journal's web site (www.jbc.org) since March 15. Coauthors are Paola Arlotta, Ph.D., and Albert K.-F. Tai, both of The Schepens Eye Research Institute; Guidalberto Manfioletti, Ph.D., University of Trieste, Italy; Charles Clifford, Ph.D., Charles Rivers Laboratories, Wilmington, Mass.; and Gilbert Jay, Ph.D., OriGene Technologies, Rockville, Md.

Previous epidemiologic data had shown that the HMG I-C gene is defective in many mesenchymal tumors. The Ono team has proven a direct role for the HMG I-C gene in lipoma formation by creating transgenic mouse lines that overexpress the defective HMG I-C gene in all cells of the body. The transgenic mice are obese early in life and develop tumors of the adipose (fat) tissue in adult life. About 25 percent of the transgenic mice develop tumors, while control mice, or normal mice, showed no evidence of tumor formation.

The researchers also found that no tumors formed in o
'"/>

Contact: Larry Bernard
bernard@vision.eri.harvard.edu
617-912-2548
Schepens Eye Research Institute
25-Apr-2000


Page: 1 2

Related biology news :

1. Obesity sleuths find chronic diseases linked to behavior contrary our DNA
2. New clock gene uncovered
3. Super-effective jumping gene created
4. Scripps Research scientists find deafness genes function
5. Ageing gene could be passed on via X chromosome
6. Role in Type 1 diabetes provides clue for researchers who discovered obesity gene
7. Discovery of how prolactin travels to genes machinery helps explain its role in breast cancer
8. Mighty mice are less susceptible to muscular dystrophy genes effects
9. New cholesterol disorder discovered As predicted from genes role
10. Investigating a protective gene against alcoholism
11. Scientists at UCLAs Jonsson Cancer Center discover genes role in regulating stem cells in the brain

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Obesity gene causes cancer fat tissue Schepens scientists find

(Date:10/30/2014)... A UT Arlington bioengineering professor has received a ... aims to regenerate cartilage tissue and reduce osteoarthritis ... the injection of microscaffolding made of biodegradable polymers., ... of the bioengineering department, said the research is ... injured on the battlefield., "We,ve found that if ...
(Date:10/30/2014)... North Carolina State University researchers have developed a suite ... between dogs and humans, which has applications in everything ... our pets. , "We,ve developed a platform for computer-mediated ... to new avenues for interpreting dogs, behavioral signals and ... Dr. David Roberts, an assistant professor of computer science ...
(Date:10/29/2014)... study of its kind to date, researchers have used ... the risk for autism. Joseph Buxbaum, Ph.D., Icahn School ... Daly, Ph.D., Broad Institute of Harvard and MIT, and ... affected children, parents and unrelated people. They identified changes ... the risk for autism spectrum disorder (ASD) – a ...
Breaking Biology News(10 mins):UTA researcher uses microscaffolding injections to mend cartilage, prevent osteoarthritis 2New tech aims to improve communication between dogs and humans 2
(Date:10/30/2014)... October 29, 2014 Global polyvinyl chloride ... world economic crisis during 2008-2009, especially in North America ... and currently is keeping to a growing trend. , ... is utilized in the construction segment. In 2013, the ... profiles, tubing, sheets and rigid film. Moreover, the PVC ...
(Date:10/30/2014)... James Sherley says he has been working towards ... since his days as a principal investigator at the Fox ... Sherley founded the ASCTC as a new Boston biotech ... property developed in Sherley’s research over the years since FCCC, ... (MIT), and more recently as a senior scientist at the ...
(Date:10/30/2014)... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), the leader ... company overview at the Nomura Biotechnology Conference on Thursday, November ... MA. A live webcast of the ... of the Company,s website, www.isispharm.com .  A replay will ... will be archived for a limited time. About ...
(Date:10/27/2014)... Ryan Carfley , Managing Partner at ... with Bryan Hamilton, the publisher of the Triangle Business Journal, ... the Research Triangle region of North Carolina. , Just a ... roundtable include the role of social media in recruitment, ... and the unique role that Millennials play in the workplace ...
Breaking Biology Technology:Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3
Cached News: