Obscure Enzyme May Play Major Role In Heart Disease

NEW YORK, N.Y. and HAIFA, Israel, April 14, 1998 -- A little-known enzyme may play a significant role in preventing heart attack. A paper appearing April 15 in the prestigious Journal of Clinical Investigation, reports that paraoxonase, an enzyme present in the blood, prevents the oxidation of low-density lipoprotein or LDL, the "bad cholesterol" that is deposited in blood vessels and leads to coronary heart disease. The paper is by Professor Michael Aviram, a biochemist, head of the Lipid Research Laboratory, Faculty of Medicine at the Technion-Israel Institute of Technology and at Rambam Medical Center in Haifa, Israel.

"Paraoxonase is located in the blood on the HDL, the 'good' cholesterol, and it can break down oxidized LDL to non-harmful products," explains Aviram, adding that the discovery of this enzyme's activity opens a possible new route to prevention of heart diseases.

The real function of the enzyme has been something of a mystery since it was discovered more than 40 years ago. Its previously known function was to break down organophosphates, chemicals that are used as insecticides and poison gases. That activity was obviously not the complete story of paraoxonase, as humans do not normally contain these substances in their blood, Aviram realized.

Since the major focus of his past research has been the study of the mechanisms by which oxidized cholesterol and other oxidized lipids accumulate in arterial wall cells, leading to blockage of arteries and formation of atherosclerotic lesions, he decided to study the effect of the enzyme on oxidized lipids. Researchers had previously found a very strong inverse relationship between the activity of paraoxonase in the blood and the risk of heart disease. Lower activity is associated with higher risk. The present study helps us understand the mechanism behind that relationship.

In experiments with a

Contact: Martha Molnar
(212) 307-2580
American Society for Technion - Israel Institute of Technology

Page: 1 2 3

Related biology news :

1. Colorado State Scientists Tackle Genetic Makeup Of Obscure Bacteria
2. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
3. Enzyme activation appears key in helping internal clock tell night from day
4. Enzyme fully degrades mad cow disease prion
5. Enzyme revealed that is key to funguss ability to breach immune system
6. Enzyme discovery sheds light on causes of rare disease, cancer
7. Enzyme could overcome industrial bleaching waste problems
8. Enzyme controls good cholesterol
9. Enzyme discovery to benefit homeland security, industry
10. Enzyme could aid cancer fight
11. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment

Post Your Comments:

(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com ... just published the overview results from the Q1 wave ... the recent wave was consumers, receptivity to a program ... data with a health insurance company. "We ... to share," says Michael LaColla , CEO of ...
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
Breaking Biology Technology:
Cached News: