Old brains can learn new tricks!

A study led by the Rotman Research Institute at Baycrest Centre for Geriatric Care in Toronto has found that older people use different areas of the brain to perform the same 'thinking task' as young.

The study, in conjunction with University of Toronto and Brandeis University in Massachusetts, is published in the Oct. 25 international journal "Current Biology". While other studies have conducted comparisons of young and old brain activity, this is the first to focus on how the interplay of brain regions relates to cognitive functioning and aging.

"The older brain is more resilient than we think," says Dr. Randy McIntosh, Rotman scientist and assistant professor, Department of Psychology, at University of Toronto. "If aging brains can find ways to compensate for cognitive decline, this could have exciting implications for memory rehabilitation."

Ten young adults (ages 20 to 30) and nine older adults (ages 60 to 79) participated in identical visual, short-term memory tests while their brain activity was measured using positron emission tomography (PET). PET measures regional cerebral blood flow and acts as a marker to show which brain areas are 'lighting up' during a memory performance task.

Participants were shown pairs of vertical grid patterns on a computer screen and asked to select which one had the higher spatial frequency. After viewing each pair, they would press one of two keys to indicate the correct grid. Researchers measured their ability to discriminate stimuli over half-second and four-second intervals.

Results show that young and older participants perform the memory task equally well, but the neural systems or pathways supporting performance differed between young and old. While there was some overlap in the brain regions supporting performance (e.g. occipital, temporal and inferior prefrontal cortices), the neural communication among these common regions was much weaker in older individuals.

Older individuals compensated f

Contact: Kelly Connelly

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