HOME >> BIOLOGY >> NEWS
One gene, two important proteins

When the Human Genome Project first revealed last year that humans possess only an estimated 30,000 genes - fives times more than a mustard weed plant - the fact that many genes code for more than just one protein assumed greater importance. Such protein variations, researchers reasoned, must play an even larger role in contributing to the remarkable complexity of human beings.

This notion has been supported recently by Rockefeller University scientists, who report the discovery of a novel protein variation within a single fruit fly gene, or "gene locus." Specifically, they show that the fly's one and only "STAT" gene locus - the human counterpart of which plays a role in cancer - codes for a second protein that inhibits the activity of the originally characterized STAT protein.

In this post-genomic era, findings like this one make it more and more clear that alternate proteins, or protein isoforms, should be considered when attempting to explain complex biological phenomena, says James E. Darnell Jr., Ph.D., principal author of the report published in the Sept. 15 issue of Genes and Development.

The discovery of an inhibitory STAT protein suggests possible novel treatments for the approximately 50 percent of human cancers in which STAT proteins are known to be overactive. These include leukemia, breast cancer and head and neck cancer.

Other authors of this research paper include first authors Melissa A. Henriksen, Ph.D., and Aurel Betz, Ph.D., and second author Marc V. Fucillo, all from The Rockefeller University. Darnell is the head of the Laboratory of Molecular Cell Biology at Rockefeller and co-author of the popular textbook Molecular Cell Biology.

The STAT genes, first identified by the Darnell laboratory in 1992, code for a set of proteins that help cells throughout the body to interpret and respond to dozens of incoming chemical messages. They are found in a variety of organisms, from slime molds to humans, and are ess
'"/>

Contact: Whitney Clavin
clavinw@rockefeller.edu
212-327-7250
Rockefeller University
14-Sep-2002


Page: 1 2 3 4

Related biology news :

1. Plant immune systems take two aspirin gene, offers hope for disease control
2. Mouse, stripped of a key gene, resists diabetes
3. Study suggests interplay of gene, stress can predict depression
4. One gene, two eye diseases?
5. Study to help solve health problems by understanding gene, protein behavior in cells
6. Researchers characterize mollusk insulin gene, find unique peptide
7. Breast cancer relapse rates appear higher in women who have cancer-causing gene, Yale study finds
8. Genetic map of important tree genes outlined
9. Maternal DHA levels plays important role in infant development
10. PTC Therapeutics researchers identify biochemical pathway important for modulating cell growth
11. New tumor suppressor may play important role in deadly brain tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass webinars, ... revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory foods ... AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & Food ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... a publication detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to ... in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the ...
(Date:6/28/2020)... (PRWEB) , ... June 25, ... ... of enterprise software solutions for biopharmaceutical R&D, today announced that it has ... developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational and clinical ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode ... significant expansion of laboratory operations through its COVID-19 testing service, Bode-CARES . ... , Bode-CARES provides a turnkey solution that includes a comprehensive ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT ... Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: ... hosted an elite awards program, highlighting outstanding examples of how technology innovations and ...
Breaking Biology Technology:
Cached News: