HOME >> BIOLOGY >> NEWS
Oral Vaccine Protects Infants From Severe Rotavirus Diarrhea

An oral vaccine against rotavirus -- the most important cause of life-threatening diarrhea in children under age 2 -- reduced severe diarrheal illness by 88 percent in a study of more than 2,000 infants in Venezuela. This is the largest and most successful trial to date of a rotavirus vaccine among children in a developing country.

Worldwide, rotavirus diarrhea affects 130 million infants and children each year, some 18 million of whom have moderate to severe disease, resulting in 873,000 deaths.

The study was conducted by Albert Z. Kapikian, M.D., head of the Epidemiology Section of the Laboratory of Infectious Diseases (LID), part of the National Institute of Allergy and Infectious Diseases (NIAID); Irene Perez-Schael, M.D., chief of the Laboratory of Enteric Disease at the Instituto de Biomedicina, Universidad Central de Venezuela in Caracas; and their co-workers. Results are reported Oct. 23 in The New England Journal of Medicine.

"This is the first study designed to determine if the vaccine prevents severe illness in a developing country where rotavirus circulates year-round rather than seasonally," explains Anthony S. Fauci, M.D., NIAID director. "In this setting, the vaccine proved to be very efficacious."

Although rotavirus infection is nearly universal, "The outcome and consequences of rotavirus illness in developed countries are very different from those in developing countries," Dr. Perez-Schael says. Children in developing countries more often develop severe and fatal illness.

Symptoms develop quickly and, in addition to diarrhea, include vomiting, fever and dehydration. In severe cases, a child can experience 10 to 20 episodes of diarrhea and 10 to 15 vomiting episodes per day. Dehydration can be reversed through oral rehydration therapy or, if more serious, through hospitalization and intravenous fluids. Although effective, these therapies are not readily a
'"/>

Contact: Laurie K. Doepel
ldoepel@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
22-Oct-1997


Page: 1 2 3 4 5 6

Related biology news :

1. Hope Clinic of Emory Vaccine Center receives CDC contract
2. Vaccines against foodborne disease on horizon
3. GenVec, U.S. NMRC, and PATHs Malaria Vaccine Initiative partner to expand malaria vaccine efforts
4. Vaccine technique shows potential against common form of lung cancer
5. Fighting fire with fire? Vaccine based on chimp virus shows promise against HIV
6. Emory Vaccine Research Center study identifies specific gene required for long-term immunity
7. Vaccine prevents stroke in rats
8. Vaccine puts blood-sucking ticks off their food
9. Vaccine protects against fatal West Nile complication
10. Dr. Robert C. Gallo to Collaborate with Visiting Israeli Scientist on Promising HIV Vaccine Research at Marylands Institute of Human Virology
11. Vaccine controls AIDS in monkeys, researchers report in Science

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: