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Oral administration of estrogen replacement therapy suppresses the biological actions of growth hormones in GH-deficient women

alf of this dose during the transdermal phase. Comparable IGF-I levels between estrogen treatments were obtained at a GH dosage ~1.0 IU higher during oral estrogen treatment.

The Metabolic Study

IGF-I results confirmed the findings of the dose-response study. Thus, mean baseline IGF-I concentration during oral estrogen was significantly lower than during transdermal estrogen. GH administration increased IGF-I levels during both estrogen treatments, with a mean IGF-I level lower during oral estrogen treatment. Furthermore, the increase in IGF-I induced by GH was also of lower magnitude during the oral phase compared with the transdermal phase.

Lipid oxidation

Fasting lipid oxidation was not influenced by the route of estrogen administration. Ingestion of a standardized meal significantly suppressed lipid oxidation during both estrogen treatment. When compared with the transdermal route, oral estrogen administration resulted in a greater suppression of lipid oxidation during the 1st h after ingestion of the standardized meal. Fasting and postmeal lipid oxidation was significantly increased by growth hormone treatments, although the meal once again induced a decline in lipid oxidation during both estrogen treatments. However, postmeal lipid oxidation during GH treatment was again suppressed to a greater degree in the first hour with oral treatment. The magnitude of GH-induced stimulation of lipid oxidation during fasting or in the postmeal state was not influenced by the route of estrogen. Thus oral estrogen reduces early postprandial lipid oxidation both before and during GH administration.

Protein metabolism

When compared with the transdermal phase, leucine incorporation into protein was significantly lower during the oral phase. Mean leucine turnover was lower during oral therapy, although the difference failed to reach statistical significance. Leucine oxidation was not significantly different between estrogen treatment
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Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
30-Nov-2001


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