Oral administration of estrogen replacement therapy suppresses the biological actions of growth hormones in GH-defic...( ges may occur with conventional oral es...)

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Oral administration of estrogen replacement therapy suppresses the biological actions of growth hormones in GH-deficient women

ges may occur with conventional oral estrogen therapy in untreated GH-deficient women.

The study concludes that:

- Estrogen at a therapeutic dose exerts significant route-dependent effects on GH action in women with organic GH deficiency.

- Compared with the transdermal route, oral estrogen aggravates metabolic abnormalities of GH deficiency and attenuates the metabolic effects of GH therapy. Thus oral estrogen may worsen the body composition abnormalities of GH deficiency and limit the benefits of GH replacement therapy in GH-deficient women.

- The route of estrogen administration is an important consideration both before and during GH replacement therapy in hypogonadal GH-deficient women.

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Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
30-Nov-2001

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