Other Highlights in the July 3 Iss...( were treated with the nitric oxide-vit...)

were treated with the nitric oxide-vitamin B12 analogue plus interferon β, which increases expression of the receptor that takes vitamin B12 into cells, the tumors were eradicated. The authors suggest that the vitamin B12 analogue inhibited tumor growth by inducing apoptosis, or cell death. The findings appear in the July 3 issue of the Journal of the National Cancer Institute.

Aminopeptidase Helps Leukemia Cells Resist Death:
One type of leukemia cell, called NB4, expresses high levels of a cell-surface protein called aminopeptidase and, unlike other types of leukemia cells, does not appear to undergo cell death induced by endothelial cell-derived interleukin 8. To find out why, Kiyohiko Hatake, Ph.D., of the Japanese Foundation for Cancer Research in Tokyo, and his colleagues examined aminopeptidase activity in several leukemia cell lines. When the authors increased levels of aminopeptidase, they found that the leukemia cells resisted apoptosis induced by IL-8. However, the addition of bestatin, an inhibitor of aminopeptidase, restored the cells' ability to undergo apoptosis. The authors conclude that bestatin may be useful for treating patients with leukemia.

Mechanism Suggested For Insulin and Colon Cancer:
Studies have suggested that certain dietary and associated factors may increase the risk of colorectal cancer by changing blood insulin concentrations, but the mechanism has been unclear. In the July 3 issue of the Journal of the National Cancer Institute, Manjinder S. Sandhu, M.Sc., of the University of Cambridge, and colleagues review data on the biologic interactions among insulin, insulin-like growth factor I (IGF-I), and insulin-like growth factor proteins (IGFBPs). They suggest that elevated insulin levels may block the production of one or more IGFBPs, leading to an increase in IGF-I, a molecule that can promote tumor cell growth and inhibit tumor cell death.

Attribution to th
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Contact: Linda Wang
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
2-Jul-2002

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