HOME >> BIOLOGY >> NEWS
Other Highlights in the June 2 JNCI

Biomarker Could Help Detect Prostate Cancer
A new study shows how testing for an immune response to the prostate cancer biomarker alpha-methylacyl-CoA racemase (AMACR) could be used to help detect prostate cancer in men with intermediate prostate-specific antigen (PSA) levels.

Although PSA screening for prostate cancer has become widespread in the United States, the test has a high rate of false positives because benign diseases, such as prostate enlargement, can increase PSA levels. AMACR expression has been shown to be increased in prostate cancers, but AMACR levels in blood are too low to be detected.

To determine whether an immune response to AMACR could be used instead as a biomarker for prostate cancer, Arul M. Chinnaiyan, M.D., Ph.D., of the University of Michigan Medical School in Ann Arbor, and colleagues used protein microarrays to look for an immune response to AMACR in patients with prostate cancer and in healthy control subjects. The patients with prostate cancer all had a higher immune response to AMACR compared with the control subjects. The authors suggest that the test may be useful in detecting prostate cancer and reducing the number of biopsies done, particularly in men who have intermediate PSA levels.

In an editorial, H. Ballentine Carter, M.D., and William B. Isaacs, Ph.D., of Johns Hopkins School of Medicine in Baltimore, write, "The value of the present study may be the proof of principle that screening for an immune response to cancer-specific antigens by using protein microarrays could lead to improved biomarkers of disease."

Contact: Sally Pobojewski, Senior Science Writer, University of Michigan Medical School, 734-764-2220, pobo@umich.edu

More Effective Method of PLK1 Gene Silencing Inhibits Tumor Growth
The therapeutic use of gene silencing through RNA interference with small interfering RNAs is limited because its effects last for at
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
1-Jun-2004


Page: 1 2 3 4

Related biology news :

1. Other highlights in the September 1 JNCI
2. Other highlights in the August 18 JNCI
3. Other highlights in the August 4 JNCI
4. Other highlights in the July 7 JNCI
5. Other highlights in the June 16 JNCI
6. Other highlights in the May 19 JNCI
7. Other highlights in the May 5 JNCI
8. Other highlights of the March 17 issue of JNCI
9. Other highlights in the March 3 issue of JNCI
10. Other highlights in the February 18 issue of JNCI
11. Other highlights in the February 4 issue of JNCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/25/2019)... ... August 23, 2019 , ... Sierra Instruments is pleased ... to their online store are now live. Sierra has redesigned entry to the site ... format is more user-friendly and easier to navigate with streamlined menus and simple access ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... cell line for rapid and low-cost biomanufacturing of complex protein therapeutics, today announced ... member of AbSci's Scientific Advisory Board, Dr. Larimore brings more than 30 years ...
(Date:8/19/2019)... ... August 19, 2019 , ... Since the ... of ultra-thin two dimensional slices which are placed on microscope slides, stained and ... tissues and complicated features such as vasculature and thus researchers in the last ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, a clinical ... distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on the 2019 ... special issue. , As the executive vice president of business development and marketing ...
(Date:8/4/2019)... (PRWEB) , ... August 02, 2019 , ... Cirtec Medical ... invasive devices, today announced that it has begun construction on a 30,000 sq. ft. ... 15 miles from San Jose. , The facility, which is expected to be ...
(Date:7/26/2019)... BOSTON (PRWEB) , ... July 25, 2019 , ... ... senior-level biopharma leaders through off-the-record collaboration and dialogue, today announces its Boston ... Boston Waterfront Hotel. As part of Biotech Week Boston , the event ...
(Date:7/19/2019)... ... July 18, 2019 , ... Global precision motion ... their current piezo motion facilities in Lederhose, Germany, increasing their current footprint by ... ceramic assembly production in addition to general office space, a significant increase to ...
Breaking Biology Technology:
Cached News: