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Chromosomal Regions Containing Possible Prostate Cancer Susceptibility Genes Identified

A new study has identified five chromosomal regions that are likely to harbor prostate cancer susceptibility genes.

Prostate cancer is the second leading cause of cancer death among men in the United States. Family history is one of the most well-established risk factors for the disease, but no genes that confer prostate cancer susceptibility have been found to date.

In an analysis of 426 families with histories of prostate cancer, Jeffrey M. Trent, Ph.D., of the Translational Genomics Research Institute in Phoenix, and Jianfeng Xu, M.D., Dr.PH., of Wake Forest University School of Medicine in Winston-Salem, N.C., and colleagues found evidence of a prostate cancer susceptibility gene on the long arm of chromosome 17. In addition, four other regions that might hold susceptibility genes were identified among specific subsets of families. Further fine mapping studies will be needed to identify any prostate cancer susceptibility genes in these regions, the authors say.

Contacts:

  • Wake Forest University: Karen Richardson (krchrdsn@wfubmc.edu) or Shannon Koontz (shkoontz@wfubmc.edu), 336-716-4587
  • TGen: Galen Perry, Director of Communications, 602-343-8423, gperry@tgen.org

    Gene Mutation Associated With Lower Risk of Prostate Cancer Found

    Men who carry a specific mutation in the MIC-1 gene may have a lower risk of developing prostate cancer than men who do not have the mutation, according to a new study. Henrik Grnberg, Ph.D., of Ume University in Ume, Sweden, and colleagues had hypothesized that variations in the MIC-1 gene, which is thought to play an important role in the inflammatory response to infection, could be associated with the risk of prostate cancer.

    Contact: Henrik Grnbe
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  • Contact: Sarah L. Zielinski
    jncimedia@oupjournals.org
    301-841-1287
    Journal of the National Cancer Institute
    17-Aug-2004


    Page: 1 2 3

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