ut its association with response to taxane-based chemotherapy is not clear. Dennis J. Slamon, M.D., Ph.D., of the University of California, Los Angeles, and colleagues analyzed retrospective data from a randomized clinical trial that had treated patients with metastatic breast cancer with either taxane-based epirubicinpaclitaxel (ET) chemotherapy or epirubicincyclophosphamide (EC) chemotherapy.
They found that HER-2/neu overexpression does not adversely influence response to first-line ET or EC chemotherapy and that a taxane-containing regimen, such as ET, may provide a preferential benefit to patients with tumors that overexpress HER-2/neu.
Contact: Kim Irwin, Women's Cancer Program Area, Jonsson Cancer Center, 310-206-2805, firstname.lastname@example.org
Researchers Examine Targeted Therapy for Neuroblastoma in Mouse Model
Survival is poor in patients with advanced-stage neuroblastoma, a cancer of nerve cells in infants and children, and there is a need to develop better treatments. Mirco Ponzoni, Ph.D., of G. Gaslini Children's Hospital in Genoa, Italy, and colleagues show that by encapsulating an antisense oligonucleotide targeting an oncogene and activating the innate immune system in a liposome that specifically targets neuroblastoma cells, neuroblastoma-bearing mice lived longer than mice given any other treatment in the study.
Contact: Mirco Ponzoni, G. Gaslini Children's Hospital, 39-010-563-6342, email@example.com
Also in the August 4 JNCI:
No Survival Benefit for Adjuvant Chemotherapy for Colon Cancer after 10 Years:
Activated Signaling Pathway May Predict Lung Cancer Patients' Response to Gefitinib:
Contact: Sarah L. Zielinski
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