fective and less damaging to the kidneys than the traditional three daily doses in children with fever and neutropenia (reduced white blood cell count) who are undergoing stem cell transplantation, according to a study of 60 children randomly assigned to the two regimens. Lillian Sung, M.D., of the Hospital for Sick Children in Toronto, and her colleagues, conclude that "once-daily dosing with tobramycin should be adopted for children with febrile neutropenia, including children who are undergoing stem cell transplantation."

Contact: Laura Greer, Hospital for Sick Children, 416-813-5046, laura.greer@sickkids.ca.

Titles of additional articles appearing in the December 17 JNCI:

• Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression, Luc Willems, Universitaire des Sciences Agronomiques de Gembloux, Gembloux, Belgium, et al.
• Effect of epidermal growth factor receptor inhibitor on development of estrogen receptornegative mammary tumors: http://www.eurekalert.org/emb_releases/2003-12/jotn-ods121103.php
• Adjuvant chemotherapy followed by goserelin versus either modality alone for premenopausal lymph nodenegative breast cancer: A randomized trial: http://www.eurekalert.org/emb_releases/2003-12/jotn-sst121103.php

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Contact: Katherine Arnold
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
16-Dec-2003

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