HOME >> BIOLOGY >> NEWS
Other highlights in the July 17 issue of JNCI

Elevated Protein Levels May Be a Diagnostic Marker for Bladder Cancer
A new study suggests that testing urine for elevated levels of a protein involved in the initiation of DNA replication may be a tool to detect bladder cancer. The results appear in the July 17 issue of the Journal of the National Cancer Institute.

The gold standard test for diagnosing bladder cancer is cystoscopy, or an examination of the bladder through a cystoscope that is inserted into the body through the urethra. However, the test is invasive and costly, and the symptoms of bladder cancer (blood in the urine and pain when urinating) that could prompt cystoscopy can also indicate the presence of a less serious condition. A simple urine test, called urine cytology, to detect the presence of abnormal cells in the urine is also used to diagnose bladder cancer; however, the test has low sensitivity (the ability to detect disease in people who actually have the disease).

The minichromosome maintenance (Mcm) family of proteins plays a critical role in regulating the initiation of DNA replication. Previous studies have suggested that expression of these proteins is a marker of epithelial carcinogenesis.

Kai Stoeber, M.D., of the University of Cambridge, Gareth Williams, Ph.D., of University College London, and colleagues tested whether measuring Mcm5 levels in urine could detect the presence of bladder cancer. They tested the urine of 353 patients with urinary tract symptoms or urothelial neoplasia who were going to have cystoscopies. They found that the Mcm5 test had a higher sensitivity (i.e., was more likely to yield a positive result in people who actually have bladder cancer) than urine cytology. They also found that patients with prostate cancer had higher levels of Mcm5 in their urine than men without prostate cancer, although the authors caution that this observation was based on a small number of patients.

Also in the July 17 JNCI'"/>

Contact: Linda Wang
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
16-Jul-2002


Page: 1 2 3

Related biology news :

1. Other highlights in the September 1 JNCI
2. Other highlights in the August 18 JNCI
3. Other highlights in the August 4 JNCI
4. Other highlights in the July 7 JNCI
5. Other highlights in the June 16 JNCI
6. Other Highlights in the June 2 JNCI
7. Other highlights in the May 19 JNCI
8. Other highlights in the May 5 JNCI
9. Other highlights of the March 17 issue of JNCI
10. Other highlights in the March 3 issue of JNCI
11. Other highlights in the February 18 issue of JNCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... ... October 15, 2018 , ... ... solutions for highly regulated industries, is a silver sponsor and exhibitor at the ... , The Biomanufacturing World Summit brings together the “who’s who” of ...
(Date:10/13/2018)... ... October 12, 2018 , ... ... host a booth at premier packaging event PACK EXPO International in Chicago from ... Manufacturers Institute (PMMI), of which HOLLOWAY AMERICA is a member. , At this ...
(Date:10/11/2018)... ... October 10, 2018 , ... ... newly diagnosed breast cancer patients to learn about their treatment options. The unique ... with triple negative breast cancer (TNBC), and was developed through a collaboration between ...
Breaking Biology News(10 mins):
(Date:10/11/2018)... ... October 11, 2018 , ... ... and software solutions, in collaboration with HP, the global leader in printing, has ... GHS Chemical Labels on all HP PageWide Printers. , The award-winning Avery UltraDuty ...
(Date:10/5/2018)... ... October 04, 2018 , ... ... along with Duke University, announced today at IDWeek™ 2018 the positive results of ... pathogen DNA in plasma, accurately identified causative pathogens in patients with infective endocarditis ...
(Date:10/5/2018)... ... October 04, 2018 , ... Earthres ... website that elevates the company’s brand identity and better reflects its current breadth ... broader range of engineering expertise and related support services to clients in seven ...
(Date:10/2/2018)... ... October 02, 2018 , ... ... for biopharmaceutical R&D, today announced a new out-of-the-box integration of the ... leading international pharmaceutical and laboratory equipment supplier. This enables the automatic import ...
Breaking Biology Technology:
Cached News: