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Other highlights in the July 7 JNCI

argeted Therapy for Some Thyroid Cancers Identified

A new study identifies RPI-1, a Ret tyrosine kinase inhibitor, as a possible targeted therapy for the treatment of some thyroid cancers.

About 30% of medullary thyroid carcinomas are inherited, either as part of the multiple endocrine neoplasia type 2 (MEN2) syndromes MEN2A and MEN2B or the related disease, familial medullary thyroid carcinoma. Patients with medullary thyroid carcinoma can only be cured through surgery, which is only be performed before the cancer has metastasized clinically, as the cancer does not respond to standard chemotherapy or radiation.

Cinzia Lanzi, Ph.D., of the Istituto Nazionale Tumori in Milan, Italy, and colleagues tested the effects of the novel 2-indolinone RET tyrosine kinase inhibitor RPI-1 on a mouse model of MEN2A medullary thyroid carcinoma. When delivered orally, RPI-1 had a strong antitumor effect. The authors conclude that RPI-1's antitumor efficacy and oral bioavailability make it potentially useful to target Ret oncoproteins in humans.

In an editorial, Samuel A. Wells, M.D., and Joseph R. Nevins, Ph.D., of Duke University Medical Center in Durham, N.C., address potential strategies for targeted cancer therapy and discuss the importance of RET inhibitors to slow the growth of thyroid tumors.

Contact: Franco Zunino, Istituto Nazionale Tumori, 39-02-2390-2267, franco.zunino@istitutotumori.mi.it


Study Finds Possible Mechanism for Acrylamide's Mutagenicity

Acrylamide, a known rodent carcinogen, is found in many commonly consumed foods, including breakfast cereals, french fries, and potato chips. Although the mechanism by which acrylamide exerts its carcinogenic effect is unclear, acrylamide and its primary metabolite glycidamide are mutagenic. A new study reports a possible mechanism by which acrylamide mutates DNA and causes cancers.


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Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
6-Jul-2004


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