Other highlights in the June 16 JNCI

lid target for the treatment of gastric cancer.

Contact: Laura Sussman, Communications Office, M. D. Anderson Cancer Center, 713-745-2457, lsussman@mdanderson.org

Study Elucidates Molecular Interactions of Bone Sialoprotein in Cancer Cell Invasion

Although bone sialoprotein (BSP) is overexpressed in many malignant tissues, including breast, lung, prostate, and thyroid cancers, its role in tumor progression has remained unknown. In a new study, Abdullah Karadag, M.D., Ph.D., of the National Institute of Dental and Craniofacial Research in Bethesda, Md., and colleagues looked into whether BSP's interaction with other molecules enhances the invasiveness of cancer cells. They found that when BSP and two other molecules--matrix metalloproteinase 2 and integrin alphavbeta3--form a cell-surface trimolecular complex, cancer cells appear to become more invasive.

Contact: Robert Kuska, National Institute of Dental and Craniofacial Research, 301-594-7560, kuskar@mail.nih.gov

Also in the June 16 JNCI:

  • Review: Ductal Carcinoma In Situ, Complexities and Challenges (Leonard et al.)
  • Study Investigates Tamoxifen Resistance and Possible Way to Reverse It: http://www.eurekalert.org/emb_releases/2004-06/jotn-sib061004.php
  • Calcium Supplements Associated with Decreased Risk of Large Bowel Polyps: http://www.eurekalert.org/emb_releases/2004-06/jotn-csa061004.php


  • Contact: Sarah L. Zielinski
    Journal of the National Cancer Institute

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