HOME >> BIOLOGY >> NEWS
Outcome for acute lymphoblastic leukemia linked to gene expression patterns

esistance genes and treatment outcome."

In addition, the researchers found that there is no universal cross-resistance gene that would block sensitivity to all four drugs. Rather, genes linked to resistance belonged to different functional categories (i.e., they did different tasks in the cell) and these differed for each medication.

"Learning the function of these genes gives us new insights into the causes of resistance to individual drugs used to treat children with ALL," said Monique den Boer, co-author of the study and head of the research laboratory of Pediatric Oncology/Hematology at the Erasmus University.

The study further supports the practice of combination anti-cancer drug therapy to treat ALL.

"The fact that resistance genes fall into groups that perform different functions in the cells demonstrates the importance of using combination therapy to treat cancer," said Ching-Hon Pui, M.D., director of the St. Jude Leukemia/Lymphoma division, the F.M. Kirby Clinical Research Professor for the American Cancer Society and a co-author of the paper.

Combination therapy allows physicians to use multiple anti-cancer drugs to attack different biochemical functions simultaneously.


'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
4-Aug-2004


Page: 1 2 3

Related biology news :

1. High Temperature Immediately Following A Stroke Leads To Worse Outcome; Quick Cooling Shown To Have Benefit
2. Surgical Experience Improves Thyroidectomy Outcome
3. Chromosomal Abnormalities Key For Prediting Leukemia Outcome
4. Colorado State Biology Professor Says Fatty Acids, Not Shadow, Determine Outcome Of Groundhog Day Feb. 2
5. Gene profiles could improve acute leukemia diagnosis and lead to better treatments
6. Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia
7. Bat saliva drug and new MRI techniques offer hope for acute stroke treatment
8. Mutation may help cause acute myeloid leukemia
9. Cox-2 enzyme plays important role regulating acute pancreatitis and associated lung injury
10. UT Southwestern researchers say overdoses of acetaminophen cause most cases of acute liver failure
11. World Trade Center clean-up workers report acute respiratory problems

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/12/2018)... ... September 12, 2018 , ... Captiva ... announced today it has received 510(k) clearance from the U.S. Food and Drug ... MIS Pedicle Screw System. , TowerLOX-EXT MIS Extended Tab Pedicle Screws provide the ...
(Date:9/1/2018)... ... ... this minute, Frenchman Ben Lecomte is hard at work on his second ocean crossing. After ... new challenge: going from Tokyo to San Francisco, churning his limbs eight hours a day ... As the first expedition of its kind, The Swim is far more than just an ...
(Date:8/31/2018)... Wash., and CARDIFF, Wales (PRWEB) , ... August ... ... Space Agency. Martha Sanchez, senior scientist, IBM Research. Jacklyn Novak, infrared materials engineer, ... of Katherine Johnson, the NASA mathematician who just celebrated her 100th birthday. Today, ...
Breaking Biology News(10 mins):
(Date:8/17/2018)... ... August 16, 2018 , ... The opening of the new Titusville facility ... Services in 2016. Chemko had a well established local presence, servicing the Space Coast ... projects such as the ongoing work at the Mobile Launch Platform (MLP) in support ...
(Date:8/17/2018)... ... August 16, 2018 , ... Ambry Genetics ... the AmbryShare project were published today in JAMA Oncology, identifying new and confirming ... ever conducted. , Every year hereditary breast cancer affects more than 20,000 women ...
(Date:8/14/2018)... , ... August 13, 2018 , ... ... chemical fume hoods and biological safety cabinets. In addition, Labconco produces other lab ... one measure of its commitment to quality and consistency in design and manufacturing. ...
(Date:8/14/2018)... ... 14, 2018 , ... The growing interest in PEEK-OPTIMA™ spinal ... Association of Orthopaedic Surgeons (CAOS) held in partnership with the North American Spine ... and Invibio Biomaterial Solutions partnered to demonstrate the new Uplifter® Expandable ...
Breaking Biology Technology:
Cached News: