HOME >> BIOLOGY >> NEWS
Outcome for acute lymphoblastic leukemia linked to gene expression patterns

esistance genes and treatment outcome."

In addition, the researchers found that there is no universal cross-resistance gene that would block sensitivity to all four drugs. Rather, genes linked to resistance belonged to different functional categories (i.e., they did different tasks in the cell) and these differed for each medication.

"Learning the function of these genes gives us new insights into the causes of resistance to individual drugs used to treat children with ALL," said Monique den Boer, co-author of the study and head of the research laboratory of Pediatric Oncology/Hematology at the Erasmus University.

The study further supports the practice of combination anti-cancer drug therapy to treat ALL.

"The fact that resistance genes fall into groups that perform different functions in the cells demonstrates the importance of using combination therapy to treat cancer," said Ching-Hon Pui, M.D., director of the St. Jude Leukemia/Lymphoma division, the F.M. Kirby Clinical Research Professor for the American Cancer Society and a co-author of the paper.

Combination therapy allows physicians to use multiple anti-cancer drugs to attack different biochemical functions simultaneously.


'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
4-Aug-2004


Page: 1 2 3

Related biology news :

1. High Temperature Immediately Following A Stroke Leads To Worse Outcome; Quick Cooling Shown To Have Benefit
2. Surgical Experience Improves Thyroidectomy Outcome
3. Chromosomal Abnormalities Key For Prediting Leukemia Outcome
4. Colorado State Biology Professor Says Fatty Acids, Not Shadow, Determine Outcome Of Groundhog Day Feb. 2
5. Gene profiles could improve acute leukemia diagnosis and lead to better treatments
6. Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia
7. Bat saliva drug and new MRI techniques offer hope for acute stroke treatment
8. Mutation may help cause acute myeloid leukemia
9. Cox-2 enzyme plays important role regulating acute pancreatitis and associated lung injury
10. UT Southwestern researchers say overdoses of acetaminophen cause most cases of acute liver failure
11. World Trade Center clean-up workers report acute respiratory problems

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... ... July 09, 2019 , ... ... Genetic Research into its incubator program. The founder and CEO of Tx Genetic, ... the lives of those suffering from epithelial connective tissue disorders. , “We are ...
(Date:6/25/2019)... ... June 25, 2019 , ... ActX has launched a ... available from 23andMe, customers can get access to professionally reviewed genetic screening similar ... 23andMe Ancestry and Health + Ancestry customers., With the ActX + 23andMe service, ...
(Date:6/16/2019)... ... June 14, 2019 , ... ... lecture at the fifth annual Neodent World Congress. Attended by thousands of dental ... and latest advancements in the world of dentistry. The three-day event featured a ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... , ... June 10, 2019 , ... ... its distribution network with the appointment of Biofeedback Tech Ltd as ... systems are an essential part of many therapeutic treatments and clinical assessment protocols ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... will add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed ... DeepDyve’s continually expanding library of more than 20 million articles, sourced from more ...
(Date:6/11/2019)... ... June 11, 2019 , ... Veterinary Regenerative Medicine company, ... , has announced that their GMP facility for cell production is now approved ... This is an important milestone for VetStem as it expands into contract ...
(Date:6/6/2019)... ... June 05, 2019 , ... WCCT Global, Inc ... device industries, announced today that they will be receiving 3 awards at the 2019 ... WCCT received 2 awards in the categories of overall Quality and Compatibility (Access to ...
Breaking Biology Technology:
Cached News: