HOME >> BIOLOGY >> NEWS
Ovarian cancer sheds tumor suppression with loss of estrogen receptor

An important receptor for estrogen in ovarian cells has been shown to suppress tumor growth, according to a new study published in the August 15 issue of the journal Cancer Research. When ovarian tumors develop, however, the number of these receptors--known as estrogen receptor beta (ER beta)--diminishes, encouraging these tumors to advance toward malignancy and metastasis. This disappearing act may help explain why ovarian cancers are often typically resistant to anti-estrogen drugs including Tamoxifen.

"Ovarian cancer is remarkably lacking in response to antiestrogens such as Tamoxifen," Gwendal Lazennec, Ph.D., research group leader in molecular and cellular endocrinology of cancers at Inserm U540, Montpellier, France. "We hypothesized that this may be due to the selective decrease that we observed in the expression of message for ER beta in tumors from ovarian cancer patients."

Tumors from 58 ovarian cancer patients contained less messenger RNA for the ER beta than found in ovarian samples from healthy patients, said Lazennec, whose team included scientists from France and Italy. To understand how the loss of ER beta affected the ovarian cells during cancer progression, the gene for ER beta was replaced in ovarian cancer cell lines that no longer expressed the estrogen-triggered nuclear receptor. The ER beta reintroduced into the cancer cell lines did not share the classic functions attributed to estrogen receptors, including induction of progesterone receptor expression and fibuline-1C, and it's ability to decrease the expression of the cyclin D1 gene was completely opposite of it's counterpart, ER beta.

Furthermore, the restored ER beta induced apoptosis, or cell death, in the ovarian cancer cells.

"ER beta appears to have important regulatory functions in the control of the proliferation and motility of ovarian cancer," Lazennec said. "With the loss of ER beta in ovarian cells, ovarian cancers shed the restrictive properties
'"/>

Contact: Russell Vanderboom, PhD
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
15-Aug-2004


Page: 1 2

Related biology news :

1. Ovarian tumor cell sensitivity then resistance - to chemotherapy linked to genetic abnormality
2. Ovarian cancer detected in blood samples
3. Ovarian stimulation in mice adversely affects embryo development and implantation
4. Study Suggests Vaccine Increases Survival In Ovarian And Breast Cancer Patients Following High-Dose Chemotherapy And Autologous Stem Cell Transplant
5. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer
6. Gene Knockout Prolongs Ovarian Lifespan In Mice
7. Gene Once Thought To Program Ovarian Development Instead Found To Be Critical For Production Of Sperm
8. Cold Virus With P53 Gene Tested To Combat Ovarian Cancer
9. Multi-Center Study Provides Guidelines For Genetic Testing In Women With Breast Cancer: BRCA Abnormalities Multiply Risk Of Ovarian Cancer
10. Leader in cancer treatment and prevention research honored
11. International study findings link acne-like rash to effectiveness of new targeted cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: