HOME >> BIOLOGY >> NEWS
Ovarian cancer sheds tumor suppression with loss of estrogen receptor

An important receptor for estrogen in ovarian cells has been shown to suppress tumor growth, according to a new study published in the August 15 issue of the journal Cancer Research. When ovarian tumors develop, however, the number of these receptors--known as estrogen receptor beta (ER beta)--diminishes, encouraging these tumors to advance toward malignancy and metastasis. This disappearing act may help explain why ovarian cancers are often typically resistant to anti-estrogen drugs including Tamoxifen.

"Ovarian cancer is remarkably lacking in response to antiestrogens such as Tamoxifen," Gwendal Lazennec, Ph.D., research group leader in molecular and cellular endocrinology of cancers at Inserm U540, Montpellier, France. "We hypothesized that this may be due to the selective decrease that we observed in the expression of message for ER beta in tumors from ovarian cancer patients."

Tumors from 58 ovarian cancer patients contained less messenger RNA for the ER beta than found in ovarian samples from healthy patients, said Lazennec, whose team included scientists from France and Italy. To understand how the loss of ER beta affected the ovarian cells during cancer progression, the gene for ER beta was replaced in ovarian cancer cell lines that no longer expressed the estrogen-triggered nuclear receptor. The ER beta reintroduced into the cancer cell lines did not share the classic functions attributed to estrogen receptors, including induction of progesterone receptor expression and fibuline-1C, and it's ability to decrease the expression of the cyclin D1 gene was completely opposite of it's counterpart, ER beta.

Furthermore, the restored ER beta induced apoptosis, or cell death, in the ovarian cancer cells.

"ER beta appears to have important regulatory functions in the control of the proliferation and motility of ovarian cancer," Lazennec said. "With the loss of ER beta in ovarian cells, ovarian cancers shed the restrictive properties
'"/>

Contact: Russell Vanderboom, PhD
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
15-Aug-2004


Page: 1 2

Related biology news :

1. Ovarian tumor cell sensitivity then resistance - to chemotherapy linked to genetic abnormality
2. Ovarian cancer detected in blood samples
3. Ovarian stimulation in mice adversely affects embryo development and implantation
4. Study Suggests Vaccine Increases Survival In Ovarian And Breast Cancer Patients Following High-Dose Chemotherapy And Autologous Stem Cell Transplant
5. UI Researchers Find Possible Genetic Link Between The X Chromosome And Ovarian Cancer
6. Gene Knockout Prolongs Ovarian Lifespan In Mice
7. Gene Once Thought To Program Ovarian Development Instead Found To Be Critical For Production Of Sperm
8. Cold Virus With P53 Gene Tested To Combat Ovarian Cancer
9. Multi-Center Study Provides Guidelines For Genetic Testing In Women With Breast Cancer: BRCA Abnormalities Multiply Risk Of Ovarian Cancer
10. Leader in cancer treatment and prevention research honored
11. International study findings link acne-like rash to effectiveness of new targeted cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... , ... August 25, 2020 , ... Modality Solutions, ... Inc. magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ranking ... 2019 as well, and for this year’s list, reported three-year revenue growth of 71 ...
(Date:8/21/2020)... (PRWEB) , ... August 20, 2020 , ... ... that Hassan Movahhed , a Clinical Operations executive with expertise in clinical ... has joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed ...
(Date:8/5/2020)... Fla. (PRWEB) , ... August 05, 2020 , ... Regenative ... cover two new innovations, CoreText™ and ProText™, making them the first Wharton’s jelly allografts ... defect using a syringe. The company’s solutions are the first Wharton’s jelly allograft product ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... available for free its new white paper – Simulated Transport Methodologies. Regulatory ... today’s biologics licensing application (BLA). In response, Modality Solutions shares an explanation ...
(Date:8/7/2020)... ... 06, 2020 , ... VGXI, a highly regarded CDMO supporting ... purchase of greenfield for a new, expanded manufacturing facility. The site is located ... the initial acquisition, with an option to purchase an additional 21 acres for ...
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its platform ... Biologics since its formation in 2016, the company is relaunching itself under the Ardent ... its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
Breaking Biology Technology:
Cached News: