Overfeeding Normal Infant Rats Affects Three Generations: Permanently Changes Basic Metabolism, Interferes With Reproduction

NEW ORLEANS -- Some women who become glucose intolerant late in pregnancy may develop gestational diabetes and give birth to larger than normal babies with a tendency to become obese. Now a new study of genetically normal rats indicates that the effect of overfeeding extends for at least three generations and may explain health trends beginning to be seen in human populations in the American Southwest, Japan, Australia and some Pacific islands.

The fact that the overfed animals were genetically normal is important because it shows that conditions during development can have consequences several generations later, even in the absence of genetic abnormalities, emphasized a University of Washington researcher reporting on new work here today at the Society for Neuroscience's annual meeting.

The newborn rats were overfed to duplicate nutritional conditions during late human pregnancy that often affect the babies of diabetic mothers, according to Elsie Taylor, a recent Ph.D. graduate in psychology and UW researcher. Gestational diabetes occurs in 2 to 3 percent of otherwise normal human pregnancies. A mother's system regulates the amount of nutrients fed to her developing baby through the bloodstream, but pregnancy can produce a stress on the pancreas. When this happens, the pancreas sometimes can't produce enough insulin, a hormone that allows the body to use carbohydrates, triggering gestational diabetes.

Taylor says newborn rats are immature at birth so their first three weeks of life correspond to that of a human fetus in the final trimester before birth in terms of metabolic and brain development.

"Newborn rats are God's gift to developmental science," says Jaime Diaz, a UW psychology professor and Taylor's collaborator on the study. "We can study a newborn rat and learn much about maturational events which occur during late human pregn

Contact: Joel Schwarz
University of Washington

Page: 1 2 3

Related biology news :

1. Genetics Of Obesity And Of The Response To Chronic Overfeeding
2. Normal gene control increases chances human stem cells will be safe
3. Normal salt levels in the lung of the cystic fibrosis mouse
4. Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice
5. Scientists Show That Normal-looking Cells In Cervical Cancer May Be Abnormal
6. Williams Syndrome: New UD Study May Shed Light On Rare Genetic Disorder-And Normal Development
7. Evidence For Genetic Effects On The Behavior Of Normal Two-Week Old Babies
8. Infant rats eagerly accept high concentrations of alcohol upon first exposure
9. Infants sighs may reset breathing regulation mechanism as well as help lungs develop
10. Infants more vulnerable to serious brain injury from falling than previously thought
11. Researchers find a genetic connection in Sudden Infant Death Syndrome (SIDS)

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: