HOME >> BIOLOGY >> NEWS
Oxygen key switch in transforming adult stem cells from fat into cartilage

NEW ORLEANS -- In their ongoing research on turning adult stem cells isolated from fat into cartilage, Duke University Medical Center researchers have demonstrated that the level of oxygen present during the transformation process is a key switch in stimulating the stem cells to change.

Their findings were presented today (Feb. 2, 2003) at the annual meeting of the Orthopedic Research Society.

Using a biochemical cocktail of steroids and growth factors, the researchers have "retrained" specific adult stem cells that would normally form the structure of fat into another type of cell known as a chondrocyte, or cartilage cell. During this process, if the cells were grown in the presence of "room air," which is about 20 percent oxygen, the stem cells tended to proliferate; however, if the level of oxygen was reduced to 5 percent, the stem cells transformed into chondrocytes.

This finding is important, the researchers say, because this low oxygen level more closely simulates the natural conditions of cartilage, a type of connective tissue that cushions many joints throughout the body. However, since it is a tissue type poorly supplied by blood vessels, nerves and the lymphatic system, cartilage has a very limited capacity for repair when damaged. For this reason, the Duke investigators are searching for a bioengineering approach to correct cartilage injury.

"Our findings suggest that oxygen is a key determinant between proliferation and differentiation, and that hypoxia, or low oxygen levels, is an important switch that tells cells to stop proliferating and start differentiating,' said David Wang, a fourth-year medical student at Duke, who presented the results of the Duke research.

Farshid Guilak, Ph.D., director of orthopedic research and senior member of the Duke team, said that the combination of growth factors sets the adult stem cells on the right path, while controlling oxygen levels inspires the cells to more readily transf
'"/>

Contact: Richard Merritt
merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
2-Feb-2003


Page: 1 2 3

Related biology news :

1. Oxygen sensing in worms may hold key to healthy blood pressure in humans
2. Oxygen triggered the evolution of complex life forms
3. Oxygen deficiency is an endocrine disruptor in fish
4. Evolution upset: Oxygen-making microbes came last, not first
5. Oxygen is toxic to stem cells
6. Oxygen measurements yield greenhouse clues
7. Tumor Oxygen Level And Blood Flow Fluctuate, Duke Scientists Discover
8. Fake Photosynthesis? Test-Tube System In Science Paper Sheds Light On The Oxygen We Breathe, UD Prof Says
9. Oxygen-Carrying Myoglobin Not Necessary For Survival
10. Stroke Risk Increased In Patients With High Oxygen Use In Brain
11. Improved Oxygen Bath To Heal Wounds, Lessen Number Of Amputations: Sandia To Sign Agreement With Numotech To Help Create Home-Use Healing Facility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/3/2017)... -- Texas Biomedical Research Institute announced that its Board of Trustees ... the Institute,s new President and CEO. Dr. Schlesinger will take ... is currently the Chair of the Department of Microbial Infection ... Biology at Ohio State University. "We are delighted ... of Texas Biomed," said Dr. James O. Rubin , ...
(Date:2/1/2017)... , February 1, 2017 IDTechEx Research, a ... emerging technology, announces the availability of a new report, Sensors ... Continue Reading ... ... and collaborative robots. Source: IDTechEx Report "Sensors for Robotics: Technologies, Markets ...
(Date:1/25/2017)... , Jan. 25, 2017 The Elements ... Management (IAM) lifecycle is comprised of a comprehensive ... the purpose of maintaining digital identities and providing ... and applications. There are significant number of programs ... time to time by optimizing processes and changing ...
Breaking Biology News(10 mins):
(Date:2/20/2017)... Kingdom (PRWEB) , ... February 20, 2017 , ... ... manufactures industrial metal detection solutions for the food and pharmaceutical processing and packaging ... award goes to the manufacturer that has done the most or taken the ...
(Date:2/20/2017)... ... February 20, 2017 , ... PuraCath Medical, an emerging ... dialysis, announced today that it has published the result of its recent research ... International (PDI), the official Journal of the International Society for Peritoneal Dialysis ...
(Date:2/19/2017)... ... 2017 , ... Expanding Portfolio to Include Lab Equipment and ... the goal of expanding the reach of its quality and precision to additional ... meters were introduced into the market in 2014. , The OHAUS Starter Series ...
(Date:2/18/2017)... Research and Markets has announced the addition of the ... offering. ... report provides separate comprehensive analytics for the US, Japan ... Annual estimates and forecasts are provided for the period 2015 through ... Market data and analytics are derived from primary and secondary research. ...
Breaking Biology Technology:
Cached News: