HOME >> BIOLOGY >> NEWS
Oxygen sensing in worms may hold key to healthy blood pressure in humans

For life on our planet, the rule is simple: if you don't get the right amount of oxygen, you die.

For humans, living as we do in an atmosphere with a rich and stable supply of oxygen, maintaining the correct levels in our bodies is a relatively routine task. For organisms that live in soil or water, however, where oxygen levels can fluctuate wildly, the task is far more challenging -- and pretty much of a mystery, until now.

A multi-institutional collaboration of researchers that includes a scientist with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) has learned how one soil dweller, the nematode Caenorhabditis elegans, is able to sense oxygen levels in its environment and feed in areas where the concentration of oxygen is just right.

"It's surprising that more than 200 years after Antoine Laurent Lavoisier and Joseph Priestly discovered oxygen, we're still finding out how organisms sense and use it," says Michael Marletta, a chemist who holds a joint appointment with Berkeley Lab's Physical Biosciences Division and the University of California at Berkeley.

Marletta is one of the co-authors of a paper on the oxygen-sensing system, which appears in the July 15 issue of the journal Nature. Other authors are Cornelia Bargmann, who holds a joint appointment with the University of California at San Francisco and the Howard Hughes Medical Institute, plus David Karow of UC Berkeley, Jesse Gray, Hang Lu, and Andy Chang of UCSF, Jennifer Chang of the University of Michigan, and Ronald Ellis of the University of Medicine and Dentistry of New Jersey.

An enzyme points the way:

The discovery of the oxygen-sensing mechanism in nematodes actually began as an investigation into a human enzyme, guanylate cyclase, which performs signaling interactions with nitric oxide molecules critical to regulating blood pressure. When nitric oxide enters a human cell it activates guanylate cyclase, whic
'"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
14-Jul-2004


Page: 1 2 3 4 5

Related biology news :

1. Oxygen triggered the evolution of complex life forms
2. Oxygen deficiency is an endocrine disruptor in fish
3. Oxygen key switch in transforming adult stem cells from fat into cartilage
4. Evolution upset: Oxygen-making microbes came last, not first
5. Oxygen is toxic to stem cells
6. Oxygen measurements yield greenhouse clues
7. Tumor Oxygen Level And Blood Flow Fluctuate, Duke Scientists Discover
8. Fake Photosynthesis? Test-Tube System In Science Paper Sheds Light On The Oxygen We Breathe, UD Prof Says
9. Oxygen-Carrying Myoglobin Not Necessary For Survival
10. Stroke Risk Increased In Patients With High Oxygen Use In Brain
11. Improved Oxygen Bath To Heal Wounds, Lessen Number Of Amputations: Sandia To Sign Agreement With Numotech To Help Create Home-Use Healing Facility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2018)... (PRWEB) , ... August 07, 2018 , ... CallTower ... today their new CT Cloud Voice and SIP solutions. CT Cloud solutions are ... secure, quality voice solution that is far superior to traditional PBX systems, at a ...
(Date:8/1/2018)... ... August 01, 2018 , ... Dr. Asher Kimchi, Founder ... winning recipients of the 2018 IAC Awards at the 23rd World Congress on Heart ... also named four faculty to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, ...
(Date:8/1/2018)... , ... August 01, 2018 , ... Visikol CEO Dr. ... services and strong pharmaceutical company partnerships that Visikol will far exceed its original 2018 ... developing its suite of digital pathology tools, whole mount imaging ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 08, 2018 , ... ... was developed and is continually updated by a talented scientific team that includes ... service provides: , 1. Information on the medical impact of a patient’s ...
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson ... construction (AEC) experts with building owners and managers for a full-day discussion on ... Construct symposium comes to Boston for the first time on Thursday, 13 September ...
(Date:7/31/2018)... (PRWEB) , ... July 31, 2018 , ... ... 2 additional CE/IVD marked molecular quality controls to its expanding CE/IVD product inventory. ... controls to our expanding CE/IVD QC offerings. ZeptoMetrix remains entirely committed to fully ...
(Date:7/25/2018)... ... July 25, 2018 , ... Dimitrius Anagnos, an evidence-based ... combat inflammation and autoimmune disorders. , The preclinical research assessed biomarkers for ... was reported:, Over 70% decrease in Interleukin (IL-1ß) ...
Breaking Biology Technology:
Cached News: