Equally important for the future of this technology is the observation that immune responses to vaccines can be anatomically localized and measured in normal individuals," said Dr. Iyengar, who is a research associate with the Department of Molecular Microbiology and Immunology. "This could be invaluable in the evaluation of new vaccines and routes of administration."

For the study, the researchers used PET scans to examine 23 people who were HIV-positive, 12 of whom had recently been infected. The other 11 had been infected for a long period of time, but none of the participants had any signs of disease or illness. The researchers also scanned eight non-infected individuals as a control group. They were given influenza vaccine to stimulate lymph node activation.

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Contact: Tim Parsons or Kenna Brigham
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
29-Sep-2003

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