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PNNL recognized for commercializing technologies

ey normally would be lost, and a more focused transmission. The result is much greater sensitivity and the capability to measure substances, such as proteins, at much lower levels.

Through non-exclusive licensing agreements, PNNL has transferred the technology to three companies--Waters Corp., Milford, Mass., and Bruker Daltonics, Bellerica, Mass., manufacturers of mass spectrometers; and Biospect, San Francisco, Calif., which is developing a new class of instruments for human clinical applications.

Cancer Treatment

Alpha particle immunotherapy is the first treatment that targets metastatic cancers. This groundbreaking technology makes it possible to treat some types of cancer more effectively and with fewer side effects than conventional treatments, including chemotherapy, radiation therapy and surgery. Immunotherapy combines the power of alpha particle-emitting radioactive isotopes, such as actinium-225 and bismuth-213, with monoclonal antibodies that bind to and destroy specific cancer cells, while sparing nearby healthy tissues.

The PNNL-developed separations, purification and conjugate chemistry has made it possible to use these powerful new radioisotopes to treat patients with leukemia or fast-spreading cancers. Early trials at major research centers have been encouraging and a second round of clinical trails is scheduled to begin in fall 2004 at Memorial Sloan-Kettering Cancer Center in New York.

While researchers at PNNL developed the enabling chemistry, the primary supplier of the radioisotopes is MedActinium, a small radiopharmaceutical firm in Tennessee. MedActinium holds an exclusive license to the new technology, which allows them to develop immunotherapy products and bring the therapy closer to fullscale clinical use.

Collision/Reaction Cell Technology

PNNL's development of the Inductively Coupled Plasma/Mass Spectrometry (ICP/MS) Collision/Reaction Cell (CRC) Technology has resulted in a
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Contact: Lisa Brown
lisa.brown@pnl.gov
509-375-2465
DOE/Pacific Northwest National Laboratory
1-Mar-2004


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