PRAECIS announces positive results for abarelix depot-M in two pivotal Phase III clini...( New Orleans LA May 23 2000.

PRAECIS announces positive results for abarelix depot-M in two pivotal Phase III clinical trials

New Orleans, LA, May 23, 2000. - PRAECIS PHARMACEUTICALS INCORPORATED (NASDAQ: PRCS) today announced the results of two Phase III studies for its lead compound, abarelix depot-M, for the treatment of prostate cancer. PRAECIS is developing this product globally with its corporate collaborators. These two studies, which included 520 prostate cancer patients, showed the intended benefits of abarelix depot-M when compared head to head with leuprolide acetate depot or leuprolide acetate depot and bicalutamide, two drugs commonly used for treating prostate cancer. The data were presented at the 36th annual meeting of the American Society of Clinical Oncology (ASCO) in New Orleans by David McLeod, M.D., Director of Urologic Oncology at Walter Reed Army Medical Center.

Prostate cancer is one of the most commonly diagnosed cancers in men. According to the American Cancer Society, approximately 180,000 new diagnoses of, and 32,000 deaths from, prostate cancer will occur in the United States this year. Current prostate cancer therapies include surgery, radiation therapy, hormonal therapy or a combination of these. Hormonal therapies reduce the male hormone, testosterone, to low levels and are used because approximately 85% of newly-diagnosed prostate cancers are hormone-dependent tumors that require testosterone for their continued growth. Shutting off the body's normal production of testosterone, therefore, is the primary goal of hormonal treatment.

Available hormonal therapies may cause an initial surge or increase in the level of testosterone before the desired effect of lowering testosterone occurs. In the studies reported today, zero percent of the patients treated with abarelix depot-M experienced a testosterone surge compared to more than 80% of patients treated with leuprolide acetate depot, or a combination of leuprolide acetate depot plus bicalutamide. Further, abarelix depot-M suppressed testosterone levels more rapidly, achieving suppres
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Contact: Renee Connolly
renee@noonanrusso.com
917-930-8471
Noonan/Russo Communications
22-May-2000

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PRAECIS announces positive results for abarelix depot-M in two pivotal Phase III clini...( New Orleans LA May 23 2000. - PR...)