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PRAECIS announces positive results for abarelix depot-M in two pivotal Phase III clinical trials

sion by day 8 in 70% of patients compared to zero percent of patients treated with either leuprolide, or leuprolide plus bicalutamide. Each treatment therapy studied achieved and maintained testosterone suppression from day 29 through day 85 in more than 90% of patients. Reported side effects, such as hot flashes, were similar for all three hormonal treatment regimens.

"The studies show that abarelix depot-M represents a potentially new prostate cancer treatment which acts rapidly without causing a testosterone surge when therapy is initiated," said Marc B. Garnick, M.D., PRAECIS' Chief Medical Officer. "Based on the results of these trials, PRAECIS plans to continue clinical evaluation of abarelix depot-M and plans to file a New Drug Application with the United States Food and Drug Administration by fourth quarter, 2000."

"These positive clinical results validate PRAECIS' core technology for drug discovery and our ability as a company to bring pharmaceuticals through the drug development process. We look forward to advancing our other clinical programs which are aimed at treating patients suffering from other serious human diseases," said Malcolm L. Gefter, PRAECIS' President and Chief Executive Officer.


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Contact: Renee Connolly
renee@noonanrusso.com
917-930-8471
Noonan/Russo Communications
22-May-2000


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