PSA Levels Mean More Extensive Prostate Disease In Older Men

In a study of prostate cancer at different ages, Johns Hopkins researchers have found that at diagnosis, older men have more extensive disease than younger men even if their prostate specific antigen (PSA) levels are the same. PSA is a protein made by the prostate; rising blood levels suggest that the prostate is enlarged or even cancerous.

"The finding shows that both doctors and older men must be especially vigilant," says H. Ballentine Carter, M.D., associate professor of urology. "The blood test results don't necessarily mean the same level of disease when ages differ," he said. The study, presented May 31 at the annual meeting of the American Urological Association in San Diego, Calif., was done with cancers that could not be detected by digital rectal exams.

The results are a new wrinkle on a long-standing problem over deciding whether to do further testing on men with raised PSA levels, Carter says. "Lowering the PSA threshold means you pick up more small, harmless tumors. Raising the PSA threshold means you're more likely to miss life-threatening tumors. The present study gives us age as an additional guide in deciding when it might be worthwhile to do further testing in men with non-palpable prostate cancer. At any particular PSA level, a key factor in catching cancer when it is still curable is the man's age." The Hopkins team studied 492 men who had undergone surgery to remove their prostates. The men were divided into three age groups (40-50, n=69; 51-60, n=227; 61-73, n=196) and five pre-treatment PSA categories: (2.5-4.0, n=36; 4.1-6.0, n=100; 6.1-8.0, n=122; 8.1-10.0, n=76; >10.0, n=135). Patients were considered curable if the cancer was either confined to the prostate or had not spread outside the gland to lymph nodes and the seminal vesicles.

For a given PSA range, increasing age was associated with lower probability of cure. If a man 40 to 50 years old had a PSA level of 4.0, for example, he had an 89 percent chance of havi

Contact: Marc Kusinitz
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. The Reason The French Have Low Levels Of Heart Disease
2. Marine Life In South Pacific Region Found To Be Impervious To Oceans Highest Arsenic Levels
3. Breast Milk Of Women Who Eat Lake Ontario Fish Contains High Levels Of PCBs, UB Study Finds
4. For First Time In 40 Years National Jewish Researchers Report Chronic Beryllium Disease Caused By Extremely Low Levels Of Exposure
5. Residential Dust Control Fails To Reduce Blood Lead Levels In Children
6. New Hampshire Study Shows Well Water Has Higher Arsenic Levels Than Municipal Water
7. Higher Levels Of Protein May Predict Heart Disease
8. Elevated Blood Levels Of Inactive TPA Linked To Increased Stroke Risk In Young Women
9. Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers
10. USC Scientists Find That Multi-Vitamin Use And Hormone Replacement Therapy MayLower Levels Of Homocysteine
11. Stress Hormone Levels Predict Length Of Gestation In Human Pregnancy

Post Your Comments:

(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
(Date:10/9/2017)... ... , ... At its national board meeting in North Carolina, ARCS® Foundation ... of Physics and Astronomy, has been selected for membership in ARCS Alumni Hall ... 2015 Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of ...
(Date:10/7/2017)... ... October 06, 2017 , ... With ... microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical Services. ... range of contract analysis services for advanced applications. Services will leverage techniques ...
Breaking Biology Technology:
Cached News: