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PTC Therapeutics' researchers identify biochemical pathway important for modulating cell growth

s within a cell. The amount of each of these types of RNA is tightly controlled in normal cells. Proliferative diseases result in overproduction of these two types of RNA, allowing cells to grow uncontrollably. In the course of investigations aimed at understanding gene expression in human cells, PTC scientists discovered an enzyme complex that provides evidence for a novel biochemical pathway that controls the maturation of both tRNA and mRNA. Inhibitors that target the RNA processing events carried out by this enzyme complex create new opportunities for therapeutic intervention. PTC has filed worldwide patent applications to secure its ownership rights in all aspects of this discovery.

"This important finding adds to our repertoire of post-transcriptional mechanisms of RNA processing and illustrates our expertise in RNA biology. We are excited by the discovery of this novel enzyme complex and its implications in the identification of therapeutics that target novel mechanisms of post-transcriptional control processes," said Stuart W. Peltz, Ph.D., President and CEO of PTC.


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Contact: Kerri Donnelly
kdonnelly@ptcbio.com
908-222-7000 x 112
Euro RSCG Life NRP
29-Apr-2004


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