HOME >> BIOLOGY >> NEWS
Pacific Northwest team unveils largest virus proteome to date

PORTLAND, Ore., and RICHLAND, Wash. Scientists have discovered a record number of proteins for one of the largest and most complex viruses, the highly infectious and stealthy human cytomegalovirus, a team from Pacific Northwest National Laboratory and Oregon Health & Science University reported today in the October Journal of Virology.

Human cytomegalovirus, or HCMV, is a member of the herpesvirus family. HCMV infects and persists for life in 50 to 85 percent of Americans 40 years and older. Few know they are infected and show no ill effects, but HCMV is the leading viral cause of birth defects and is a serious threat to transplant and AIDS patients and others with a compromised immune system.

"Our labs identified the viral and host proteins that compose the HCMV virion," said Jay Nelson, Ph.D., director of the OHSU Vaccine and Gene Therapy Institute (VGTI) and a study co-author. "By identifying the proteins in the HCMV virion, we hope to develop new treatments for these at-risk patients."

The team discovered 71 proteins in mature HCMV, double the number previously identified. HCMV may express as many as 200 proteins at various points in its life cycle. By comparison, adenovirus, responsible for the common cold, contains about 11 proteins.

"The proteins may not all be present at the same time," said Susan Varnum, a PNNL staff scientist and the study's co-lead author, "but we believe we're seeing most that are expressed in the mature virus."

The researchers were also surprised to find that when a cell is infected, the HCMV virus incorporates into itself a huge number of that host cell's proteins, "some of which were as abundant as viral proteins, demonstrating the complexity of this common virus," explained Dan Streblow Ph.D., a research assistant professor of molecular microbiology and immunology in Nelson's lab. "In addition, one of these host cell proteins pointed us to sites in the cell where viruses are asse
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
29-Sep-2004


Page: 1 2

Related biology news :

1. New hydrothermal vents discovered as South Pacific Odyssey research begins
2. Pacific Northwest National Laboratory gets $10 million from NIH to build virtual lung
3. Anti-plume found off Pacific Coast
4. Institute for Systems Biology, Pacific Northwest National Laboratory announce collaboration
5. Pacific leatherback turtle could go extinct in 10 years
6. Pacific Northwest National Lab unveils most complete human blood-plasma proteome map to date
7. Fish, FRAMES and sticky chemicals net technology award for Pacific Northwest National Laboratory
8. DuPont to locate Asia Pacific R&D center in Shanghai
9. LabNotes -- Research highlights from Pacific Northwest National Laboratory
10. Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales
11. Salmon farms pose significant threat to salmon fisheries in the Pacific Northwest, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... HOUSTON (PRWEB) , ... May 27, 2020 , ... CrucialTrak, ... will partner with New Jersey-based Critical Environments Group (CEG) to market and sell its ... provider of data center and IT environment infrastructure optimization solutions . , ...
(Date:5/28/2020)... , ... May 28, 2020 ... ... has announced a new enzyme solution for adjunct liquefaction: AMYLEX® 6T. The ... the ability to expand into new segments with locally-sourced raw materials, improve ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... for biopharmaceutical R&D, today announced that Gritstone Oncology, Inc., a clinical-stage biotechnology ... T cell engagers and TCR-based therapeutics, has implemented Genedata Biologics ® ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... BEDFORD, Mass. (PRWEB) , ... July 29, 2020 ... ... of highly reliable, solid-state radar transmitter systems that can be configured to drive ... a single controller that can drive one or two switches in a push-pull ...
(Date:7/31/2020)... CAMBRIDGE, Mass. and SOMERSET, N.J (PRWEB) , ... ... ... a leading genome editing company, and Catalent, the leading global provider of advanced ... and consumer health products, today announced that they have entered into a strategic ...
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/22/2020)... ... , ... Join experts from Reed Tech , Gary Saner, Sr. Manager, ... hour live webinar on Thursday, August 13, 2020 at 11am EDT (4pm ... devices. Specifically, for medical devices, the NMPA has departments dealing with medical device registration ...
Breaking Biology Technology:
Cached News: