HOME >> BIOLOGY >> NEWS
Pacific Northwest team unveils largest virus proteome to date

PORTLAND, Ore., and RICHLAND, Wash. Scientists have discovered a record number of proteins for one of the largest and most complex viruses, the highly infectious and stealthy human cytomegalovirus, a team from Pacific Northwest National Laboratory and Oregon Health & Science University reported today in the October Journal of Virology.

Human cytomegalovirus, or HCMV, is a member of the herpesvirus family. HCMV infects and persists for life in 50 to 85 percent of Americans 40 years and older. Few know they are infected and show no ill effects, but HCMV is the leading viral cause of birth defects and is a serious threat to transplant and AIDS patients and others with a compromised immune system.

"Our labs identified the viral and host proteins that compose the HCMV virion," said Jay Nelson, Ph.D., director of the OHSU Vaccine and Gene Therapy Institute (VGTI) and a study co-author. "By identifying the proteins in the HCMV virion, we hope to develop new treatments for these at-risk patients."

The team discovered 71 proteins in mature HCMV, double the number previously identified. HCMV may express as many as 200 proteins at various points in its life cycle. By comparison, adenovirus, responsible for the common cold, contains about 11 proteins.

"The proteins may not all be present at the same time," said Susan Varnum, a PNNL staff scientist and the study's co-lead author, "but we believe we're seeing most that are expressed in the mature virus."

The researchers were also surprised to find that when a cell is infected, the HCMV virus incorporates into itself a huge number of that host cell's proteins, "some of which were as abundant as viral proteins, demonstrating the complexity of this common virus," explained Dan Streblow Ph.D., a research assistant professor of molecular microbiology and immunology in Nelson's lab. "In addition, one of these host cell proteins pointed us to sites in the cell where viruses are asse
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
29-Sep-2004


Page: 1 2

Related biology news :

1. New hydrothermal vents discovered as South Pacific Odyssey research begins
2. Pacific Northwest National Laboratory gets $10 million from NIH to build virtual lung
3. Anti-plume found off Pacific Coast
4. Institute for Systems Biology, Pacific Northwest National Laboratory announce collaboration
5. Pacific leatherback turtle could go extinct in 10 years
6. Pacific Northwest National Lab unveils most complete human blood-plasma proteome map to date
7. Fish, FRAMES and sticky chemicals net technology award for Pacific Northwest National Laboratory
8. DuPont to locate Asia Pacific R&D center in Shanghai
9. LabNotes -- Research highlights from Pacific Northwest National Laboratory
10. Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales
11. Salmon farms pose significant threat to salmon fisheries in the Pacific Northwest, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: