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Pacific Northwest team unveils largest virus proteome to date

mbled."

The prevalence of host proteins in the virus, Varnum said, might also suggest how the virus avoids detection by the immune system--that it's using the body's own cellular proteins as camouflage.

Before this study, a comprehensive analysis of the proteins that constitute the HCMV virion had not been possible without the development of new proteomics technologies in the PNNL lab of Richard D. Smith, a Battelle Fellow and study co-author. To conduct this research, scientists used proteomics instruments and approaches unavailable elsewhere that combine the high resolution separations of proteins with their identification at the same time, using a powerful mass spectrometer developed at PNNL.


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Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
29-Sep-2004


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