HOME >> BIOLOGY >> NEWS
Pain in the gut? Don't blame stomach acid

ant says physicians may want to re-evaluate the long-term use of omeprazole and other proton-pump-inhibiting drugs in their patients.

Together with Yana Zavros, Ph.D., an HHMI post-doctoral fellow, Merchant and colleagues compared stomach cells from normal mice with those from a strain of transgenic mice, developed at U-M, that lack the gene for producing gastrin. Their goal was to understand the feedback relationship between bacteria, pro-inflammatory factors, hormones and acid secretion in the stomach. Results are published in the January 2002 issues of Gastroenterology and The American Journal of Physiology.

Mice in the U-M studies contracted gastritis just like people do - from eating food or drinking water contaminated with bacteria. While 75 percent of people with gastritis test positive for Helicobacter pylori, many other species of bacteria can trigger inflammatory changes, too, and often co-exist with Helicobacter. No matter what type of bacteria causes the problem, it is a serious medical condition. If untreated, chronic gastritis can lead to peptic ulcers and stomach cancer.

H. pylori is the only bacterial organism in the stomach that cannot be killed by hydrochloric acid. Since Merchant wanted to study the relationship between other bacteria and gastric acid, she needed to exclude the presence of H. pylori. U-M scientists cultured and analyzed bacteria from stomach washings of all normal and gastrin-deficient mice to confirm the absence of Helicobacter. Major types of bacteria identified included Lactobacillus, Enterobacter and Staphylococcus.

U-M scientists treated infected gastrin-deficient mice and normal control mice with antibiotics for 20 days. Other mice were treated for two months with a proton-pump-inhibiting drug called omeprazole or with a combination of omeprazole and antibiotics. At the end of the treatment period, researchers compared cell changes and bacterial counts from the stomach linings of all mice.
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
15-Jan-2002


Page: 1 2 3

Related biology news :

1. Dont always believe what you see, suggests study on false memories
2. Dont drink the water: Texas A&M researcher conducting study of polluted Mexican lake
3. Dont ban embryo-based research says new chairman of European fertility organisation
4. Dont be fooled about your oral health: AAP uncovers common misconceptions
5. Dont slight the birdbrain
6. HIV-Positive Injection Drug Users Often Dont Receive Protease Inhibitors And May Not Be Aware Of The Drug
7. HIV-1 Levels In Semen Dont Correspond To Viral Levels In Blood, Say Pitt Researchers In A Report At 12th World AIDS Conference
8. Genetic Makeup May Explain Why Some Women Smokers Develop Breast Cancer While Others Dont, UB Study in JAMA Reports
9. Female gluttony blamed on male tick
10. System failure to blame for Walkerton, North Battleford outbreaks, says U of T study
11. Cant stand the pain? Your genes may be to blame

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
(Date:6/28/2020)... Fla. (PRWEB) , ... June 25, 2020 , ... In ... focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings ... Samples are collected at medical offices and are shipped to labs throughout the country. ...
(Date:6/23/2020)... Md. (PRWEB) , ... June ... ... leading provider of gene-to-protein and monoclonal antibody development services, today announced that ... protein-based products and services to the pharmaceutical, diagnostics, and research industries. The ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... DeCurtis ... environments, announced today that Derek Fournier has been appointed CEO and President. Founder ... Board, effective immediately. , “DeCurtis Corporation has been on an incredible journey ...
(Date:6/23/2020)... ... June 23, 2020 , ... Nobilis Therapeutics, ... that it has filed an Investigational New Drug application (IND) with the U.S. ... its lead drug candidate NBTX-001 in patients with panic disorder (PD). , "Adding ...
(Date:6/11/2020)... ... June 09, 2020 , ... ... I of a Small Business Innovation Research (SBIR) program funded by the National ... Rapid Toxin Detection in the Field”. The project’s goal was to engineer and ...
(Date:6/3/2020)... ... June 03, 2020 , ... ... applications of biofeedback. In the next installment, Dr. Inna Khazan will discuss the ... learn to bring their attention to the feelings, thoughts, and emotions they are ...
Breaking Biology Technology:
Cached News: