HOME >> BIOLOGY >> NEWS
Pancreatic cancer genes ID'd in most accurate study to date

ANN ARBOR, MI Being diagnosed with pancreatic cancer is like receiving a death sentence -- one that, for many patients, is carried out within weeks or months of their cancer's discovery. Less than 20 percent of patients are diagnosed in time to qualify for the only known cure an arduous operation and only 3 percent of all patients live even five years.

But a team of researchers from the University of Michigan Comprehensive Cancer Center hopes to overturn that death sentence, through studies that zero in on the genes and proteins that help pancreatic cancer grow and spread.

In a new paper in the journal Cancer Research, and through work funded by a $2.36 million grant received last week, as well as a new patient care program, the team aims to find new ways to improve diagnosis and treatment of the deadly disease.

In the paper, published May 15, the team reports finding 158 genes specific to pancreatic cancer the most accurate list to date. They used tissue samples that had been swiftly processed after being removed from patients, to preserve fragile molecules that act as telltale signatures for genes that are "turned on" or expressed.

Unlike other scientists, the U-M team was able to distinguish genes involved in cancer from those involved in a chronic inflammatory disease, pancreatitis, that's often mistaken for cancer. Both diseases produce similar scar tissue around the pear-shaped pancreas gland, which produces insulin, hormones and digestive juices. The team narrowed the list of genes down to 80 that were expressed three times more often in pancreatic cancer cells than in non-cancerous or pancreatitis cells.

As a result, the U-M team believes its results will be more applicable to making specific diagnostic tests and effective treatments. The new paper even reports their success in identifying and detecting four of the proteins 14-3-3-sigma, S100P, S100A6, Beta-4 integrin that are encoded by the cancer-specific gen
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
3-Jun-2003


Page: 1 2 3 4 5

Related biology news :

1. Pancreatic cancer blood test & gene studies show promise
2. Pancreatic cancer linked to errant reactivation of embryo cell pathway
3. Debilitating Pancreatic Disorder Linked To Cystic Fibrosis Gene
4. Marylands Death Rate For Pancreatic Cancer Surgery Reduced By Medical Regionalization
5. Leader in cancer treatment and prevention research honored
6. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
7. Chemical derived from vitamin-E shows early promise as cancer drug
8. New molecular link key to cellular proteins involved in cancer progression, other diseases
9. Phase II trials of second-generation antisense cancer drug planned following successful early study
10. Trial shows which brain cancer patients benefit from temozolomide
11. Genetic differences might help distinguish thyroid cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... N.J. (PRWEB) , ... July 01, 2020 , ... ... announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in ... the company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC , ... that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) ... with severe COVID-19. This is the first study of an XPO1 inhibitor in ...
(Date:6/23/2020)... , ... June 23, 2020 , ... ... is pleased to announce the next event in a series of TOPIQ webinars, ... The TOPIQ series of webinars was developed in response to social distancing measures ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry Association ... strong opposition to the recently introduced bicameral Facial Recognition and Biometric Technology ... federal use of nearly all biometric and related image analytics technologies, incorrectly labeling ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., announced ... June 22-24 during the American Association for Cancer Research Virtual meeting. One poster ... potent, consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
(Date:6/11/2020)... , ... June 09, 2020 , ... ... Phase I of a Small Business Innovation Research (SBIR) program funded by the ... Century: Rapid Toxin Detection in the Field”. The project’s goal was to engineer ...
Breaking Biology Technology:
Cached News: