HOME >> BIOLOGY >> NEWS
Paradox in the lungs resolved

Researchers at National Jewish Medical and Research Center have discovered that a single class of molecules serves as the immune system's gatekeeper in the lungs, damping the immune response in some situations and promoting it in others.

The findings, published in the October 3 issue of the journal Cell, resolve an apparent paradox that prevented researchers from understanding how these versatile surveillance proteins function.

"The lung collectins can effectively discriminate between conditions in the lung that warrant an immune response and those that do not," said Peter Henson, Ph.D., Professor of Pediatrics at National Jewish Medical and Research Center. "They do this with a clever mechanism, inhibiting the immune response with one end of their structure and promoting it with the other."

The immune system must ride a fine line in its protection of the lung, whose surface area covers an area about the size of a tennis court. It must quickly sound the alarm when it detects a potentially harmful organism or molecule. But it must also tolerate a certain amount of irritation without calling out the inflammatory, disease-fighting tools, that can cause damage themselves.

The two lung collectins, surfactant proteins A and D (SP-A and SP-D), are widely recognized as members of the innate immune system, sentinels capable of initiating an inflammatory response to overcome infections and promote tissue repair.

However, recent experiments with mice contradicted this widely held view and raised serious questions about the role of the lung collectins. Mice engineered to lack the lung collectins actually demonstrate an enhanced inflammatory response, while mice overexpressing the lung collectins exhibited a reduced inflammatory response.

In their paper, Dr. Henson and his colleagues resolved this paradox with experiments showing that the lung collectins actually play two roles in the lungs, damping the immune response in some situ
'"/>

Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
2-Oct-2003


Page: 1 2

Related biology news :

1. Paradox of groundwater age has implications for hydrology
2. Paradoxical Gene Suppresses Tumors Yet Makes Them Grow
3. Infants sighs may reset breathing regulation mechanism as well as help lungs develop
4. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
5. Drinking wine, particularly white wine, may help keep lungs healthy, UB study finds
6. Mice could provide the key to growing human lungs for transplant
7. Lizards and salamanders may use lungs to hear, study says
8. Cystic fibrosis patients show too little salt in lungs, will need long-lasting treatments
9. Researchers discover gene responsible for cilia, lungs natural cleaning system
10. UI researchers develop test indicating cystic fibrosis lungs are infected with bacterial biofilms
11. Marathon runners, swimmers, and cross-country skiers beware: intensive exercise is bad for your lungs

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Paradox the lungs resolved

(Date:2/5/2015)... Feb. 3, 2015 Despite a lack ... industries such as consumer electronics, automotive, storage and ... mount technology (SMT) screen printers. Innovations in electronics ... will push the adoption curve up. Meanwhile, sale ... as glue dispensers are indispensable in the production ...
(Date:1/22/2015)... Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source of ... of its new website design. "When we launched ... says Peter O,Neill , founder and CEO of FindBiometrics. ... needs involvement from the key players on a very broad ...
(Date:1/22/2015)... , Jan. 15, 2015  BellBrook Labs, a leader ... announced the launch of a TR-FRET (time resolved ... Transcreener UDP Assay, a high throughput screening assay ... assay will allow for sensitive detection of hundreds ...
Breaking Biology News(10 mins):End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
(Date:3/2/2015)... 2015 VLP Therapeutics, LLC. ("VLP"), a ... on the research and development of therapeutic and ... upon a novel and proprietary vaccine technology, today ... Grant Award from the Montgomery County Department of ... is awarded to life sciences companies in ...
(Date:3/2/2015)... , March 2, 2015 Editor ... bottom.   Moments ago, Analysts Review released ... Sunshine Heart (NASDAQ: SSH ), Synergetics ... Medical (NASDAQ: ELOS ), Spectranetics (NASDAQ: ... Review provides a single unified platform for investors, to hear ...
(Date:3/2/2015)... Global Stem Cells Group.com has ... Bioengineering Co., Ltd. and its Chinese-American founder Mingjie ... stem cells training course in the City of ... Shenzhen HANK is a biotechnology company established in ... virologist, to integrate research, development, production, and sales ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Immunovaccine Inc. ... aware of a fraudulent press release disseminated this morning ... be from Immunovaccine. This press release states that Immunovaccine ... Inc. The press release did not originate from ... contained within the press release. Please note that ...
Breaking Biology Technology:VLP Therapeutics Wins the 2015 Life Sciences Impact Grant Award from the Montgomery County Department of Economic Development 2Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 2Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 3Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 4Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3Immunovaccine Disclaims Hoax Press Release 2
Cached News: