HOME >> BIOLOGY >> NEWS
Paradox in the lungs resolved

Researchers at National Jewish Medical and Research Center have discovered that a single class of molecules serves as the immune system's gatekeeper in the lungs, damping the immune response in some situations and promoting it in others.

The findings, published in the October 3 issue of the journal Cell, resolve an apparent paradox that prevented researchers from understanding how these versatile surveillance proteins function.

"The lung collectins can effectively discriminate between conditions in the lung that warrant an immune response and those that do not," said Peter Henson, Ph.D., Professor of Pediatrics at National Jewish Medical and Research Center. "They do this with a clever mechanism, inhibiting the immune response with one end of their structure and promoting it with the other."

The immune system must ride a fine line in its protection of the lung, whose surface area covers an area about the size of a tennis court. It must quickly sound the alarm when it detects a potentially harmful organism or molecule. But it must also tolerate a certain amount of irritation without calling out the inflammatory, disease-fighting tools, that can cause damage themselves.

The two lung collectins, surfactant proteins A and D (SP-A and SP-D), are widely recognized as members of the innate immune system, sentinels capable of initiating an inflammatory response to overcome infections and promote tissue repair.

However, recent experiments with mice contradicted this widely held view and raised serious questions about the role of the lung collectins. Mice engineered to lack the lung collectins actually demonstrate an enhanced inflammatory response, while mice overexpressing the lung collectins exhibited a reduced inflammatory response.

In their paper, Dr. Henson and his colleagues resolved this paradox with experiments showing that the lung collectins actually play two roles in the lungs, damping the immune response in some situ
'"/>

Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
2-Oct-2003


Page: 1 2

Related biology news :

1. Paradox of groundwater age has implications for hydrology
2. Paradoxical Gene Suppresses Tumors Yet Makes Them Grow
3. Infants sighs may reset breathing regulation mechanism as well as help lungs develop
4. Fetal lungs provide a signal initiating labor, UT Southwestern researchers find
5. Drinking wine, particularly white wine, may help keep lungs healthy, UB study finds
6. Mice could provide the key to growing human lungs for transplant
7. Lizards and salamanders may use lungs to hear, study says
8. Cystic fibrosis patients show too little salt in lungs, will need long-lasting treatments
9. Researchers discover gene responsible for cilia, lungs natural cleaning system
10. UI researchers develop test indicating cystic fibrosis lungs are infected with bacterial biofilms
11. Marathon runners, swimmers, and cross-country skiers beware: intensive exercise is bad for your lungs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... (PRWEB) , ... April 20, 2017 , ... ... Event , this new webinar will explore challenging patient cases when screening for ... the hospital, there may be a need for bridging parental anticoagulation especially for ...
(Date:4/20/2017)... BARBARA, CALIFORNIA (PRWEB) , ... April 20, 2017 , ... ... optimization firm for the life sciences and healthcare industries, is pleased to announce ... the new established USDM subsidiary “USDM Europe GmbH” based in Germany. , Braemer ...
(Date:4/20/2017)... Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("Prometic" or the ... ("ILC") 2017 of the European Association for the Study of ... the positive effects of PBI-4050 on reduction of non-alcoholic steatohepatitis ... ... Gagnon, Vice-President of R&D Pre-clinical of Prometic "This extensive preclinical ...
(Date:4/20/2017)... ... April 20, 2017 , ... Open Therapeutics ... property (IP) sharing and commercialization model. , The Center for Advancing Innovation helps ... of this effort is bringing the IP to the attention of the entrepreneurial ...
Breaking Biology Technology:
Cached News: