HOME >> BIOLOGY >> NEWS
Parasite or partner? Study suggests new role for junk DNA

ANN ARBOR, Mich. Junk DNA is the Rodney Dangerfield of the genetics world. It makes up nearly half of all human DNA, but many scientists dismiss it as useless gibberish. A new study published online today from the June 2002 issue of Nature Genetics, however, suggests that segments of junk DNA called LINE-1 elements deserve more respect.

Conducted by scientists from the University of Michigan Medical School and Louisiana State University, the study is the first to show in mammalian cells that some human LINE-1, or L1, elements can jump to chromosomes with broken strands of DNA, slip into the break and repair the damage.

Transposable L1 elements make up 17 percent of our DNA, but very little is known about them, says John V. Moran, Ph.D., an assistant professor of human genetics and internal medicine in the U-M Medical School, who developed the first assay to identify mobile L1s in the human and mouse genomes. Until now, everyone thought L1s were just intracellular parasites in our DNA leftovers from the distant evolutionary past. The big question in the field is: Are they still there because we cant get rid of them or do they have a function?

L1s reproduce by using RNA and a process called reverse transcription to make complementary DNA copies of themselves, which can jump into other DNA sequences. Normally, L1s use an enzyme called endonuclease to cut the genetic DNA and create a space, so they can plug themselves into the genome.

We knew about the endonuclease pathway, says Tammy A. Morrish, a U-M graduate student in human genetics and first author of the paper. But we didnt know there was another mechanism that didnt require endonuclease, or that L1s could jump into existing breaks in DNA.

Morrish tested human L1s ability to repair DNA breaks in several normal and DNA-repair mutant cell lines derived from Chinese hamster ovary cells. Other researchers had demonstrated the ability of human L1s to repair DNA breaks in yea
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
12-May-2002


Page: 1 2

Related biology news :

1. Parasites enzyme structure helps address a public health issue
2. Parasites mediate plant invasions
3. Parasites prevent ants from protecting coffee plants
4. Parasite, mosquito genomes complete malaria picture
5. Parasite offers natural way to control leaf-eating slugs
6. Parasites sperm-encryption keeps species apart
7. Parasites, Not Pollution, Responsible For Some Frog Deformities, As Reported In The 30 April Issue Of Science
8. Genetic Code Of Chromosome Of Malaria Parasite Deciphered
9. Veterinary Researchers Identify Accomplice Of Calf-Killing Parasite
10. Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
11. Puppy Parasites

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Parasite partner Study suggests new role for junk DNA

(Date:6/24/2015)... , June 22, 2015 ... announced the addition of the "Huawei Ascend ... report to their offering. Huawei,s ... to the opposite direction than Apple,s and Samsung,s ... fingerprint sensor developed by Fingerprint Cards, a main ...
(Date:6/23/2015)... June 22, 2015 ... addition of the "Body-Worn Temperature Sensors Market ... and Forecast 2014 - 2020" report to ... analysis of the global body-worn temperature sensors market. ... segmented on the basis of types, care setting, ...
(Date:6/18/2015)... YORK , June 18, 2015 This ... US$ Million by the following Product Segments, which includes ... Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and Nephelometric ... the US, Canada , ... Asia-Pacific , Latin America ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
(Date:7/2/2015)... -- Amici Procurement Migrates to the Cloud ... has chosen Microsoft Cloud Solution Provider iomart ...      (Logo: http://photos.prnewswire.com/prnh/20121126/579634) , ... the bio-tech sector with a unique procurement service, helping ... help them obtain best value. Its IT platform hosts ...
(Date:7/1/2015)... PARK, N.C. and PARIS ... research firm AgBiome, and Genective, key developer of ... accelerate the discovery of new generations of insect ... for insect control to counter the realities of ... with Genective, aligning AgBiome,s unique insect control technology ...
(Date:7/1/2015)... , July 1, 2015   Neuraltus Pharmaceuticals, ... development of groundbreaking drugs to treat neurodegenerative diseases ... that Robert G. Miller , M.D., Director of ... Health,s California Pacific Medical Center in San Francisco, has ... for $1.5 million to help fund a Phase ...
(Date:7/1/2015)... 1, 2015 InferMed , ... will ... evidence-based clinical s olutions suite   ... information products and services, announced today the acquisition of  InferMed ... (CDS) technology company. InferMed,s Arezzo technology supports clinicians ...
Breaking Biology Technology:Biotech Procurement Company Moves to Office 365 with iomart 2AgBiome and Genective collaborate to create novel insect-resistant crops 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4
Cached News: