HOME >> BIOLOGY >> NEWS
Parasite or partner? Study suggests new role for junk DNA

ANN ARBOR, Mich. Junk DNA is the Rodney Dangerfield of the genetics world. It makes up nearly half of all human DNA, but many scientists dismiss it as useless gibberish. A new study published online today from the June 2002 issue of Nature Genetics, however, suggests that segments of junk DNA called LINE-1 elements deserve more respect.

Conducted by scientists from the University of Michigan Medical School and Louisiana State University, the study is the first to show in mammalian cells that some human LINE-1, or L1, elements can jump to chromosomes with broken strands of DNA, slip into the break and repair the damage.

Transposable L1 elements make up 17 percent of our DNA, but very little is known about them, says John V. Moran, Ph.D., an assistant professor of human genetics and internal medicine in the U-M Medical School, who developed the first assay to identify mobile L1s in the human and mouse genomes. Until now, everyone thought L1s were just intracellular parasites in our DNA leftovers from the distant evolutionary past. The big question in the field is: Are they still there because we cant get rid of them or do they have a function?

L1s reproduce by using RNA and a process called reverse transcription to make complementary DNA copies of themselves, which can jump into other DNA sequences. Normally, L1s use an enzyme called endonuclease to cut the genetic DNA and create a space, so they can plug themselves into the genome.

We knew about the endonuclease pathway, says Tammy A. Morrish, a U-M graduate student in human genetics and first author of the paper. But we didnt know there was another mechanism that didnt require endonuclease, or that L1s could jump into existing breaks in DNA.

Morrish tested human L1s ability to repair DNA breaks in several normal and DNA-repair mutant cell lines derived from Chinese hamster ovary cells. Other researchers had demonstrated the ability of human L1s to repair DNA breaks in yea
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
12-May-2002


Page: 1 2

Related biology news :

1. Parasites enzyme structure helps address a public health issue
2. Parasites mediate plant invasions
3. Parasites prevent ants from protecting coffee plants
4. Parasite, mosquito genomes complete malaria picture
5. Parasite offers natural way to control leaf-eating slugs
6. Parasites sperm-encryption keeps species apart
7. Parasites, Not Pollution, Responsible For Some Frog Deformities, As Reported In The 30 April Issue Of Science
8. Genetic Code Of Chromosome Of Malaria Parasite Deciphered
9. Veterinary Researchers Identify Accomplice Of Calf-Killing Parasite
10. Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
11. Puppy Parasites

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology to ... display is the latest premium product recently added to the range of products distributed ... ... ... Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... findings on what they believe could be a new and helpful biomarker for ... research. Click here to read it now. , Biomarkers are components ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a ... take place between the two entities said Poloz. ... Ottawa , he pointed to the country,s ... the federal government. ... said, "Both institutions have common economic goals, why not sit ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
Breaking Biology Technology:
Cached News: