HOME >> BIOLOGY >> NEWS
Parasite or partner? Study suggests new role for junk DNA

ANN ARBOR, Mich. Junk DNA is the Rodney Dangerfield of the genetics world. It makes up nearly half of all human DNA, but many scientists dismiss it as useless gibberish. A new study published online today from the June 2002 issue of Nature Genetics, however, suggests that segments of junk DNA called LINE-1 elements deserve more respect.

Conducted by scientists from the University of Michigan Medical School and Louisiana State University, the study is the first to show in mammalian cells that some human LINE-1, or L1, elements can jump to chromosomes with broken strands of DNA, slip into the break and repair the damage.

Transposable L1 elements make up 17 percent of our DNA, but very little is known about them, says John V. Moran, Ph.D., an assistant professor of human genetics and internal medicine in the U-M Medical School, who developed the first assay to identify mobile L1s in the human and mouse genomes. Until now, everyone thought L1s were just intracellular parasites in our DNA leftovers from the distant evolutionary past. The big question in the field is: Are they still there because we cant get rid of them or do they have a function?

L1s reproduce by using RNA and a process called reverse transcription to make complementary DNA copies of themselves, which can jump into other DNA sequences. Normally, L1s use an enzyme called endonuclease to cut the genetic DNA and create a space, so they can plug themselves into the genome.

We knew about the endonuclease pathway, says Tammy A. Morrish, a U-M graduate student in human genetics and first author of the paper. But we didnt know there was another mechanism that didnt require endonuclease, or that L1s could jump into existing breaks in DNA.

Morrish tested human L1s ability to repair DNA breaks in several normal and DNA-repair mutant cell lines derived from Chinese hamster ovary cells. Other researchers had demonstrated the ability of human L1s to repair DNA breaks in yea
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-615-6912
University of Michigan Health System
12-May-2002


Page: 1 2

Related biology news :

1. Parasites enzyme structure helps address a public health issue
2. Parasites mediate plant invasions
3. Parasites prevent ants from protecting coffee plants
4. Parasite, mosquito genomes complete malaria picture
5. Parasite offers natural way to control leaf-eating slugs
6. Parasites sperm-encryption keeps species apart
7. Parasites, Not Pollution, Responsible For Some Frog Deformities, As Reported In The 30 April Issue Of Science
8. Genetic Code Of Chromosome Of Malaria Parasite Deciphered
9. Veterinary Researchers Identify Accomplice Of Calf-Killing Parasite
10. Discovery Of Plant-Like Metabolic Pathway In Common Parasites Supplies New Targets For Therapy
11. Puppy Parasites

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/28/2017)... , February 28, 2017 News solutions ... ... Amsterdam from 14 to 16 March, Materna will ... and show how seamless travel is a real benefit for passengers. ... added biometrics to their passenger touch point solutions to take passengers ...
(Date:2/22/2017)... Feb. 22, 2017 With the biometrics ... Research identifies four technologies that innovative and agile ... significant share in the changing competitive landscape: multifactor ... authentication.   "Companies can no longer ... security," says Dimitrios Pavlakis , Industry Analyst ...
(Date:2/13/2017)...  RSA Conference -- RSA, a Dell Technologies business, ... enhance fraud detection and investigation across digital environments ... & Risk Intelligence Suite. The new platform is ... from internal and external sources as well as ... from targeted cybercrime attacks. "Fraudsters are ...
Breaking Biology News(10 mins):
(Date:2/28/2017)...  Phosphorus, a computational genomics and clinical genetic ... Phosphorus Scientific Advisory Board, an established group of ... company on the development of new products and ... http://phosphorus.com/about-us/ to learn more about the ... some of the top leaders in the field ...
(Date:2/28/2017)... , Feb. 28, 2017 WuXi AppTec, ... open-access capability and technology platform company, today announced ... Shanghai once again passed ... observations. The inspectors from FDA thoroughly ... focusing on scientific data integrity, operation infrastructure, equipment, ...
(Date:2/28/2017)... ... 2017 , ... ACEA Biosciences, a pioneer in cell analysis instrumentation and the ... (Feng) Luo as the new Vice President of Global Clinical Development. With more ... Dr. Luo will now team with Dr. Li Xu, Chief Medical Officer, and Dr. ...
(Date:2/28/2017)... and PHILADELPHIA , Feb. 28, 2017 ... held biopharmaceutical company focusing on debilitating diseases including rare ... announced that the company joins with the National Organization ... advocacy and support around the world in commemorating Rare ... unique challenges and needs of the millions of patients ...
Breaking Biology Technology:
Cached News: