Parkinson's disease genetic study progresses with $8 mil...( grant funding. Today we have proof....)

Parkinson's disease genetic study progresses with $8 million grant

grant funding. Today, we have proof."

The second phase of the study will recruit an additional 300 sibling pairs with Parkinson's disease. Participants in the trial will answer health questions, undergo a clinical examination and donate a blood sample from which DNA is extracted. Siblings do not need to live in the same part of the country since the study is being conducted at multiple sites. (See the Web site listed below for study sites.)

"Our mission in the next five years is to find the gene on chromosome two that affects families with multiple members afflicted with Parkinson's," said Dr. Foroud. "We also intend to nail down what the parkin gene does."

In addition to the nationwide study, the IU School of Medicine is conducting a related study called PROGENI CARES for residents of Indiana. This study allows friends and same-sex in-laws of individuals with Parkinson's disease to help find the affected genes. Dr. Foroud and her fellow researchers are seeking 500 individuals with Parkinson's disease and 500 unrelated individuals without the disease. Each person must be willing to donate a blood sample. Names are kept confidential and the DNA is stored with no personal identification, such as date of birth or Social Security number.

The discoveries may have an enormous impact on early detection, treatment and on the development of new and more effective drugs for treatment of Parkinson's disease, she said.

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Contact: Mary Hardin
mhardin@iupui.edu
317-274-7722
Indiana University
12-Feb-2004

Page: 1 2
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