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Pediatric Academic Societies Report Progress In Children's Health

uated for handicaps at about four years of age. One had no handicaps; six had mild handicaps, and two were severely handicapped, report Dr. Doug Derleth and Dr. William Barbaresi of the Mayo Clinic's Department of Pediatric and Adolescent Medicine. Their findings emphasize how hard it is to predict how extremely premature babies will do when they grow up, the pediatric researchers said.

  • Compacted DNA can be delivered through disrupted blood-brain barrier Researchers at Mount Sinai School of Medicine in New York have successfully disrupted the blood-brain barrier in lab rats and generated compacted protein/DNA complexes small enough to pass through the disrupted barrier, enabling them to deliver genes to the brain globally for the first time. Dr. Yiannis A. Ioannou, lead researcher and assistant professor of human genetics, gene therapy and molecular medicine at Mount Sinai School of Medicine, called crossing the blood-brain barrier and achieving global delivery of genes to the brain a major first step in developing gene therapy for diseases of the central nervous system. The next step is to apply the approach to treat laboratory animals with diseases mirroring human disorders, he said.


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  • Contact: Jennifer Donovan
    jdonovan@oeamail.umaryland.edu
    May1-5: 504/670-8502
    Pediatric Academic Societies
    4-May-1998


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